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Frequency of Endometrial Cancer Precursors Associated with Lynch Syndrome

NCT05257057 · Status: COMPLETED · Type: OBSERVATIONAL · Enrollment: 91

Last updated 2025-03-28

No results posted yet for this study

Summary

Given that there is a significant prevalence of Lynch syndrome among patients with endometrial cancer (about 5% of patients with endometrial cancer), and given there is a known risk of endometrial cancer among patients with endometrial hyperplasia (40% risk of pre-existing occult cancer with endometrial intraepithelial neoplasia), it is hypothesized that a diagnosis of endometrial hyperplasia may herald on-going risk of harboring a Lynch Syndrome gene mutation.

The purpose of this study is to examine endometrial hyperplasia specimens and compare the frequency of Lynch Syndrome gene mutations between endometrial hyperplasia and endometrial cancer subjects. This will provide a rationale and opportunity for earlier screening, and reduce colon cancer morbidity and mortality secondary to the Lynch syndrome gene.

Conditions

Interventions

DIAGNOSTIC_TEST

Immunohistochemical staining

Immunohistochemistry will be performed on the endometrial tissue specimens

Sponsors & Collaborators

  • WellSpan Health

    lead OTHER

Principal Investigators

  • Eav Lim, DO · WellSpan Health-York Cancer Center

Eligibility

Min Age
18 Years
Max Age
99 Years
Sex
FEMALE
Healthy Volunteers
Yes

Timeline & Regulatory

Start
2019-05-08
Primary Completion
2023-06-02
Completion
2023-06-02

Countries

  • United States

Study Locations

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Entities

Diseases

Read the full study record

This page highlights key information. For complete eligibility criteria, study locations, investigator contacts, and the full protocol, visit the original record on ClinicalTrials.gov.

View NCT05257057 on ClinicalTrials.gov