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Lynch Syndrome

Lynch Syndrome

Disease

Disease Profile

Lynch syndrome is an inherited condition caused by pathogenic variants in DNA mismatch repair genes, leading to markedly increased lifetime risks of colorectal and other cancers. It is often associated with early-onset cancer in affected families.

Category: hereditary cancer predisposition syndrome
Prevalence: An estimated 1 in 279 people in the United States has Lynch syndrome.

Related News

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Lynch Syndrome Research Advances Cancer Prevention and Vaccine Trials

Mar 19, 2026

Research into Lynch syndrome is advancing cancer prevention through aspirin therapy, vaccine trials, and a major North American study examining why some patients develop cancer while others remain protected.

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Lynch Syndrome Testing, Immunotherapy, and Cancer Vaccine Advances in 2026

Feb 26, 2026

Lynch syndrome patients gain access to prevention vaccines in clinical trials, while immunotherapy advances depend on universal tumor testing for microsatellite instability. Cancer vaccines are moving from research to clinical reality.

Zsofia K. Stadler Appointed Editor-in-Chief of JCO Precision Oncology

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Zsofia K. Stadler, MD, has been appointed as the next Editor-in-Chief of JCO Precision Oncology, effective July 1, 2026. She is an Attending Physician and Clinic Director at Memorial Sloan Kettering Cancer Center.

Related Clinical Trials

NCT ID	Title	Status	Phase
NCT07609901	Preventive Dendritic Cell Vaccination for Lynch Syndrome Carriers	NOT_YET_RECRUITING	PHASE3
NCT07600710	Periodontal Disease in Patients With Lynch Syndrome	NOT_YET_RECRUITING
NCT07542405	A Web-Based Program (Kindred) to Improve the Understanding of Genetic Cancer Risk and Cancer Genetic Testing in African American Families	NOT_YET_RECRUITING	NA
NCT07472686	Small Bowel Capsule Endoscopy in Lynch Syndrome	RECRUITING
NCT07450612	Liquid Biopsy and Machine Learning for Early Colorectal Cancer, Adenomas, Lynch Cancers, and Residual Disease Detection	RECRUITING
NCT07445828	Evaluation of Capsule Colonoscopy in Patients With Lynch Syndrome	NOT_YET_RECRUITING
NCT07436312	Impact of Consumption of Ultra-processed Foods in Individuals at High Risk of Cancer	RECRUITING	NA
NCT07412197	Preventive Dendritic Cell Vaccination for Lynch Syndrome	NOT_YET_RECRUITING	PHASE1/PHASE2
NCT07381985	Strategy for Management of Patients With Hereditary Cancer Syndromes (HCS) in a Rural Environment	ENROLLING_BY_INVITATION	NA
NCT07360834	Study Aiming to Test Whether Non-invasive Liquid Biopsies Can Safely Reduce Invasive Surveillance Methods in Lynch Syndrome	NOT_YET_RECRUITING	NA