Lynch syndrome is an inherited condition caused by pathogenic variants in DNA mismatch repair genes, leading to markedly increased lifetime risks of colorectal and other cancers. It is often associated with early-onset cancer in affected families.
A new U.S. clinical study will test whether provider-mediated communication of colorectal cancer genetic risk increases family genetic testing. The trial plans to enroll around 4,000 patients and relatives.
A study in stage 3 dMMR colon cancer found that atezolizumab plus chemotherapy after surgery cut recurrence and death risk by 50%. The trial enrolled 712 patients and the regimen is now included in treatment guidelines.
Research into Lynch syndrome is advancing cancer prevention through aspirin therapy, vaccine trials, and a major North American study examining why some patients develop cancer while others remain protected.
Colorectal cancer rates are rising 3% annually in adults under 50, prompting expanded screening efforts and new treatment approaches. Recent research shows promise in combination immunotherapy and vaccine strategies for advanced disease.
Daily aspirin use does not prevent bowel cancer in the general population within 5-15 years and carries immediate bleeding risks, according to a new Cochrane review. However, long-term low-dose aspirin is associated with lower colorectal cancer risk in IBD patients.
Lynch syndrome patients gain access to prevention vaccines in clinical trials, while immunotherapy advances depend on universal tumor testing for microsatellite instability. Cancer vaccines are moving from research to clinical reality.
Zsofia K. Stadler, MD, has been appointed as the next Editor-in-Chief of JCO Precision Oncology, effective July 1, 2026. She is an Attending Physician and Clinic Director at Memorial Sloan Kettering Cancer Center.
| NCT ID | Title | Status | Phase |
|---|---|---|---|
| NCT07600710 |
Periodontal Disease in Patients With Lynch Syndrome |
NOT_YET_RECRUITING | |
| NCT07542405 |
A Web-Based Program (Kindred) to Improve the Understanding of Genetic Cancer Risk and Cancer Genetic Testing in African American Families |
NOT_YET_RECRUITING | NA |
| NCT07472686 |
Small Bowel Capsule Endoscopy in Lynch Syndrome |
RECRUITING | |
| NCT07450612 |
Liquid Biopsy and Machine Learning for Early Colorectal Cancer, Adenomas, Lynch Cancers, and Residual Disease Detection |
RECRUITING | |
| NCT07445828 |
Evaluation of Capsule Colonoscopy in Patients With Lynch Syndrome |
NOT_YET_RECRUITING | |
| NCT07436312 |
Impact of Consumption of Ultra-processed Foods in Individuals at High Risk of Cancer |
RECRUITING | NA |
| NCT07412197 |
Preventive Dendritic Cell Vaccination for Lynch Syndrome |
NOT_YET_RECRUITING | PHASE1/PHASE2 |
| NCT07381985 |
Strategy for Management of Patients With Hereditary Cancer Syndromes (HCS) in a Rural Environment |
ENROLLING_BY_INVITATION | NA |
| NCT07360834 |
Study Aiming to Test Whether Non-invasive Liquid Biopsies Can Safely Reduce Invasive Surveillance Methods in Lynch Syndrome |
NOT_YET_RECRUITING | NA |
| NCT07304063 |
Overcoming Barriers to Uptake of Cascade Screening |
NOT_YET_RECRUITING | NA |
