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Short-course Radiotherapy Followed by Consolidation Chemotherapy. 2021-001206-29

NCT05253846 · Status: ACTIVE_NOT_RECRUITING · Phase: PHASE2 · Type: INTERVENTIONAL · Enrollment: 63

Last updated 2025-06-10

No results posted yet for this study

Summary

The aim of the ShorTrip trail is to evaluate the activity and the safety of total neoadjuvant strategy with FOLFOXIRI as consolidation therapy preceded by short-course radiotherapy and followed by surgery in LARC patients.

Conditions

  • Locally Advanced Rectal Cancer

Interventions

DRUG

Irinotecan

chemotherapy treatment

DRUG

Oxaliplatin

chemotherapy treatment

DRUG

Lederfolin

treatment

DRUG

5-Fluorouracil

chemotherapy treatment

RADIATION

Short-course radiotherapy

RT

PROCEDURE

TME

surgery

Sponsors & Collaborators

  • Gruppo Oncologico del Nord-Ovest

    lead OTHER

Principal Investigators

  • Roberto Moretto, MD · Azienda Ospedaliero, Universitaria Pisana

Study Design

Allocation
NA
Purpose
TREATMENT
Masking
NONE
Model
SINGLE_GROUP

Eligibility

Min Age
18 Years
Max Age
70 Years
Sex
ALL
Healthy Volunteers
Yes

Timeline & Regulatory

Start
2022-01-25
Primary Completion
2025-01-05
Completion
2028-10-30

Countries

  • Italy

Study Locations

More Related Trials

Entities

Drugs

Read the full study record

This page highlights key information. For complete eligibility criteria, study locations, investigator contacts, and the full protocol, visit the original record on ClinicalTrials.gov.

View NCT05253846 on ClinicalTrials.gov