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NGS vs Culture Outcomes for Treatment of PJI

NCT05247281 · Status: ENROLLING_BY_INVITATION · Phase: NA · Type: INTERVENTIONAL · Enrollment: 250

Last updated 2023-11-08

No results posted yet for this study

Summary

This multicenter, randomized controlled trial will compare the use of NGS and traditional culture in directing antimicrobial treatment for patients with periprosthetic joint infection.

Conditions

  • Prosthetic Joint Infection

Interventions

DIAGNOSTIC_TEST

Culture-based treatment

Medications to treat prosthetic joint infection will be chosen based on results of traditional cultures alone

DIAGNOSTIC_TEST

Next Generation Sequencing (NGS) with Culture

Medications to treat prosthetic joint infection will be chosen based results of NGS and culture

Sponsors & Collaborators

  • Center for Innovation and Research Organization

    lead NETWORK

Principal Investigators

  • Tiffany Morrison · Center for Innovation and Research Organization

Study Design

Allocation
RANDOMIZED
Purpose
DIAGNOSTIC
Masking
NONE
Model
PARALLEL

Eligibility

Min Age
18 Years
Sex
ALL
Healthy Volunteers
No

Timeline & Regulatory

Start
2022-09-21
Primary Completion
2024-05-31
Completion
2025-05-31

Countries

  • United States

Study Locations

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Read the full study record

This page highlights key information. For complete eligibility criteria, study locations, investigator contacts, and the full protocol, visit the original record on ClinicalTrials.gov.

View NCT05247281 on ClinicalTrials.gov