MedTrace Logo

Cardiac Output in Heart Failure Patients With Mechanical Pumps

NCT05195931 · Status: TERMINATED · Type: OBSERVATIONAL · Enrollment: 7

Last updated 2023-05-19

No results posted yet for this study

Summary

This study will be looking at how cardiovascular hemodynamics, including cardiac output and flow through a left ventricular assist device (LVADs), change in response to alterations in preload, afterload, and contractility, and also during exercise, in humans with heart failure who are supported by LVADs.

Conditions

  • Heart Failure, Systolic
  • Mechanical Circulatory Support
  • Cardiovascular Hemodynamics

Interventions

DIAGNOSTIC_TEST

preload challenge

reduction in preload by head-up tilt and increase in preload with saline infusion

DIAGNOSTIC_TEST

afterload challenge

reduction in afterload with nitroprusside and increase in afterload with phenylephrine

DIAGNOSTIC_TEST

contractility assessment

heart rate changes will be made by increasing heart rate with external pacemaker/defibrillator. Contractility will be adjusted by dobutamine infusion. Patients will exercise at a constant pump speed and also with pump speed increases.

Sponsors & Collaborators

  • University of Colorado, Denver

    lead OTHER

Eligibility

Min Age
18 Years
Max Age
80 Years
Sex
ALL
Healthy Volunteers
No

Timeline & Regulatory

Start
2021-06-08
Primary Completion
2022-08-25
Completion
2022-08-25

Countries

  • United States

Study Locations

More Related Trials

Read the full study record

This page highlights key information. For complete eligibility criteria, study locations, investigator contacts, and the full protocol, visit the original record on ClinicalTrials.gov.

View NCT05195931 on ClinicalTrials.gov