MedTrace Logo

Novel Diagnostic and Disease Stage Biomarkers in AD

NCT05175664 · Status: COMPLETED · Type: OBSERVATIONAL · Enrollment: 350

Last updated 2025-05-13

No results posted yet for this study

Summary

This study will investigate the efficacy of novel biomarkers, namely blood-based biomarkers, pupillometry and actigraphy to track and predict progression of Alzheimer's disease (AD). Furthermore, the study will investigate the diagnostic value of pupillometry and actigraphy for AD.

Conditions

  • Alzheimer Disease
  • Mild Cognitive Impairment
  • Neuro-Degenerative Diseases
  • Vascular Dementia
  • Dementia With Lewy Bodies
  • Healthy Controls

Interventions

OTHER

Long-term study

No intervention. Investigations: cognitive tests, blood samples, pupillometry, actigraphy, and FDG-PET/MR brain scan.

OTHER

Short-term study

No intervention. Investigations: blood samples and pupillometry.

OTHER

Cross-sectional study

No intervention. Investigations: cognitive tests, pupillometry and actigraphy.

Sponsors & Collaborators

  • Danish Dementia Research Centre

    lead NETWORK

Principal Investigators

  • Frederikke Kragh Clemmensen, MD · Danish Dementia Research Centre, Rigshospitalet, Copenhagen, Denmark

  • Mathias Holsey Gramkow, MD · Danish Dementia Research Centre, Rigshospitalet, Copenhagen, Denmark

  • Kristian Steen Frederiksen, MD, PhD · Danish Dementia Research Centre, Rigshospitalet, Copenhagen, Denmark

  • Steen Gregers Hasselbalch, DMSc · Danish Dementia Research Centre, Rigshospitalet, Copenhagen, Denmark

  • Anja Hviid Simonsen, MSc Pharm PhD · Danish Dementia Research Centre, Rigshospitalet, Copenhagen, Denmark

Eligibility

Min Age
30 Years
Max Age
110 Years
Sex
ALL
Healthy Volunteers
No

Timeline & Regulatory

Start
2022-01-01
Primary Completion
2024-12-01
Completion
2024-12-01

Countries

  • Denmark

Study Locations

More Related Trials

Entities

Diseases

Read the full study record

This page highlights key information. For complete eligibility criteria, study locations, investigator contacts, and the full protocol, visit the original record on ClinicalTrials.gov.

View NCT05175664 on ClinicalTrials.gov