MedTrace Logo

Measuring and Modulating Changes in EEG Resting State Functional Connectivity During Short-term and Long-term Pain

NCT05158309 · Status: COMPLETED · Phase: NA · Type: INTERVENTIONAL · Enrollment: 24

Last updated 2022-03-15

No results posted yet for this study

Summary

Background and aims: Experimental prolonged pain models can shed more light on the cortical mechanisms involved in the transition from acute to chronic pain including changes in resting state functional connectivity (rsFC). This experiment aimed at examining the effect of 24-hour-capsaicin application on the rsFC of the default mode network (DMN), a prominent network in the dynamic pain connectome.

Methods: Electroencephalographic (EEG) rsFC measured by Granger causality was acquired at baseline, 1-hour, and 24-hour following the initial patch application (placebo or capsaicin). After 24 hours, the patch was cooled down then heated up to assess rsFC changes in response to pain relief and facilitation. Pain was induced using a topical capsaicin patch (or placebo as control) on the right forearm and assessed on a 0-10 numerical rating scale (NRS).

Conditions

  • Prolonged Pain, EEG, Resting State Functional Connectivity

Interventions

OTHER

8% Capsaicin patch

Cutaneous pain was induced using a (5x10 cm) 8% topical capsaicin patch (transdermal patch, 'Qutenza', Astellas) on the volar part of the dominant right forearm (5 cm from the wrist) of each participant.

OTHER

placebo patch

A transparent patch with no formulation or effect but the same size of the capsaicin patch was applied to the same location.

Sponsors & Collaborators

  • Danish National Research Foundation

    collaborator OTHER

  • European Commission

    collaborator OTHER

  • Aalborg University

    lead OTHER

Principal Investigators

  • Thomas Graven-Nielsen, DMSc, PhD · Aalborg University

Study Design

Allocation
NON_RANDOMIZED
Purpose
BASIC_SCIENCE
Masking
SINGLE
Model
CROSSOVER

Eligibility

Min Age
19 Years
Max Age
44 Years
Sex
ALL
Healthy Volunteers
Yes

Timeline & Regulatory

Start
2021-05-31
Primary Completion
2021-11-06
Completion
2021-11-06

Countries

  • Denmark

Study Locations

More Related Trials

Entities

Companies

Read the full study record

This page highlights key information. For complete eligibility criteria, study locations, investigator contacts, and the full protocol, visit the original record on ClinicalTrials.gov.

View NCT05158309 on ClinicalTrials.gov