Asymptomatic and Pre-symptomatic Transmission of SARS-CoV-2 in a Community Congregant Setting

Summary

The overall aim of this study is to measure how transmission of COVID-19 occurs in communities - including the role of super spreaders and/or identifying conditions that may increase transmission risk, with a focus on congregant situations. In order to identify how presence of symptoms and behavior affects the transmissibility of the virus, the investigators will measure SARS-CoV-2 in exhaled breath of asymptomatic and symptomatic persons using polyvinyl alcohol (PVA) test strips embedded in face masks (Face Mask Sampling- "FMS") - an innovative, non-invasive method for detection of SARS-CoV-2 in exhaled air.

Conditions

• COVID-19
• SARS-CoV2 Infection

Interventions

DEVICE

Polyvinylalcohol strip [diagnostic]

The investigators will measure SARS-CoV-2 in exhaled breath of asymptomatic and symptomatic persons using PVA test strips embedded in face masks (FMS) - an innovative, non-invasive method for detection of SARS-CoV-2 in exhaled air. Utilizing this approach, the study aims to utilize the test results extracted from the masks to identify risk factors for SARS-CoV-2 transmission and timing of infectious period in exposed people (pre-symptomatic, asymptomatic, and symptomatic).

Sponsors & Collaborators

• Colorado State University

  collaborator OTHER

• University of Colorado, Boulder

  collaborator OTHER

• Colorado Mesa University

  collaborator OTHER

• Regis University

  collaborator OTHER

• Denver Health Medical Center

  collaborator OTHER

• University of Colorado, Colorado Springs

  collaborator OTHER

• University of Colorado, Denver

  collaborator OTHER

• Colorado School of Public Health

  lead OTHER

Principal Investigators

• Geoffrey Winstanley, PharmD · Colorado School of Public Health

• Molly Lamb, PhD · Colorado School of Public Health

• May Chu, PhD · Colorado School of Public Health

• Thomas Jaenisch, MD, PhD · Colorado School of Public Health

Eligibility

Min Age

18 Years

Sex

ALL

Healthy Volunteers

Yes

Timeline & Regulatory

Start

2021-03-15

Primary Completion

2022-03-09

Completion

2022-09-01

Countries

• United States

Study Locations