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A Research Platform to Screen Healthcare Workers- Coordinated Approach to Pandemic Trials of COVID-19

NCT04574765 · Status: COMPLETED · Type: OBSERVATIONAL · Enrollment: 7373

Last updated 2025-07-10

No results posted yet for this study

Summary

Recent studies have shown that some individuals may be asymptomatic but continue to shed the COVID-19 virus. These individuals may represent a population that can unknowingly transmit the virus. Healthcare workers (HCW) may acquire COVID-19 from the community or from possibly infected patients. It is important to gather data with respect to this to further understand the prevalence of asymptomatic carriage in individuals who work in research facilities, offices and clinical areas of hospitals and research facilities/institutes since this has important implications for infection control, as well as staff and patient safety. The purpose of this study is to test whether a proportion of these individuals may be asymptomatic shedders of the COVID-19 virus.

Conditions

  • Healthcare Worker
  • Covid19

Interventions

DIAGNOSTIC_TEST

Nasopharyngeal swab

Nasopharyngeal swab for COVID-19

OTHER

Questionnaire collection (CITF)

Fill out questionnaires regarding exposures and travel history, occupation category, any symptoms in the past 21 days, any face-to-face care of a known COVID-19 positive patients in past 14 days or any children at home who are less than 12 years of age.

OTHER

Optional blood collection

Provide blood samples to look for COVID-19 specific antibodies and/or proteins at the time of enrollment and after 8 weeks.

OTHER

Optional questionnaire completion (mental health)

Fill out an optional mental health questionnaire.

DIAGNOSTIC_TEST

Optional saliva sample (for validation)

Provide saliva sample anonymously.

DIAGNOSTIC_TEST

Nasal Swab (rapid antigen test)

Panbio nasal swab rapid antigen test

Sponsors & Collaborators

  • University Health Network, Toronto

    lead OTHER

Principal Investigators

  • Amit M Oza, MD · University Health Network, Toronto

Eligibility

Min Age
18 Years
Sex
ALL
Healthy Volunteers
Yes

Timeline & Regulatory

Start
2020-04-16
Primary Completion
2021-02-03
Completion
2021-02-03

Countries

  • Canada

Study Locations

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Read the full study record

This page highlights key information. For complete eligibility criteria, study locations, investigator contacts, and the full protocol, visit the original record on ClinicalTrials.gov.

View NCT04574765 on ClinicalTrials.gov