RVF and Other Emerging Infectious Diseases in East and Central Africa

Summary

Rift Valley fever (RVF), a disease transmitted from livestock (cattle, sheep, goats, camels) to humans more commonly occurs in the East and Central Africa (ECA) regions where more than 15 major epidemics affecting more than one country have been reported over the past 50 years. Within the region, there are specific areas, referred to as hotspots, which support RVF virus maintenance via low-level virus circulation between animals, humans, and mosquitoes. Most outbreaks originate from these hotspots. Our goal is to conduct studies in RVF hotspots in four ECA countries, Kenya, Uganda, Tanzania, and Democratic Republic of Congo (DRC) to determine the burden of RVF disease among humans, wildlife and livestock during inter-epidemic periods (IEPs) and discover circulation of undetected infectious diseases. This information is important for use in developing an early warning system and possibly a vaccination strategy. The study will take place in Uganda, Kenya, Tanzania and Democratic Republic of Congo

Conditions

• Rift Valley Fever
• Hemorrhagic Fevers, Viral

Interventions

OTHER

Evidence of past or recent RVF exposure

Detection of RVF exposure.

Sponsors & Collaborators

• National Institute of Allergy and Infectious Diseases (NIAID)

  collaborator NIH

• Emory University

  collaborator OTHER

• Washington University School of Medicine

  collaborator OTHER

• Kenya Medical Research Institute

  collaborator OTHER

• University of Nairobi

  collaborator OTHER

• The International Livestock Research Institute (ILRI)

  collaborator OTHER

• MRC/UVRI and LSHTM Uganda Research Unit

  collaborator OTHER

• Sokoine University of Agriculture

  collaborator OTHER

• Institut National de Recherche Biomédicale. Kinshasa, République Démocratique du Congo

  collaborator OTHER

• Institute of Tropical Medicine, Belgium

  collaborator OTHER

• Charite University, Berlin, Germany

  collaborator OTHER

• Kenya Ministry of Health

  collaborator OTHER_GOV

• Ministry of Agriculture Livestock Fisheries and Cooperatives, Kenya

  collaborator UNKNOWN

• Ministry of Agriculture, Animal Industry and Fisheries, Uganda

  collaborator UNKNOWN

• Ministry of Health, Uganda

  collaborator OTHER_GOV

• Ministry of Public Health, Democratic Republic of the Congo

  collaborator OTHER_GOV

• Ministry of Agriculture, Fisheries and Livestock, Democratic Republic of Congo

  collaborator UNKNOWN

• Washington State University

  lead OTHER

Principal Investigators

• M. Kariuki Njenga, PhD · Washington State University

Eligibility

Min Age

2 Years

Sex

ALL

Healthy Volunteers

Yes

Timeline & Regulatory

Start

2021-10-08

Primary Completion

2025-12-31

Completion

2025-12-31

Countries

• Democratic Republic of the Congo
• Kenya
• Tanzania
• Uganda

Study Locations