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From Micro- to Macro-vessels : Water, Salt, Heart and Kidneys

NCT05114291 · Status: COMPLETED · Type: OBSERVATIONAL · Enrollment: 72

Last updated 2025-09-15

No results posted yet for this study

Summary

Hypertension is a public health concern and affects nearly a third of the French population. It can be complicated by visceral impact (including brain, heart and kidney complications) as well as on vessels especially large arteries, responsible for arterial stiffening. There are close interactions between heart and kidneys, as well as between large arteries and micro-vessels. These relationships also involve the water and salt balance and its regulatory mechanisms. Urinary concentration abilities are closely linked to the renal medullary blood flow, which in itself depends on the integrity of renal micro vessels, thus influencing the water and salt balance. Few previous studies evaluated the interconnections between renal urinary concentration abilities and blood pressure. A previous-one reported a positive relation between pulse pressure and urinary concentration in men, suggesting that subjects with higher urinary osmolarity could present a higher cardiovascular risk. Carotid-femoral pulse wave velocity represents the gold standard for non-invasive arterial stiffness assessment and constitutes an arteriosclerosis infra-clinical marker recommended by the European Society of Cardiology- European Society of Hypertension. It is considered as an independent predictor for global and cardiovascular mortality, coronary heart disease and fatal stroke among patients with hypertension, diabetes or end stage kidney disease. The purpose of this study is to evaluate the relations between fasting urinary osmolarity and arterial stiffness assessed by carotid-femoral pulse wave velocity (CF-PWV) among patients with hypertension.

Conditions

Interventions

OTHER

Explorations are planned as part of the one-day hospitalization

* Clinical parameters : Interrogation, physical examination, morphological data measurements (weight, height, waist circumference, hip circumference) and impedencemetry (body composition). * Biological samples : Blood and urine exam, fasting urine sample (urinary osmolarity) * Standardized blood pressure measurement : * After 5 to 10 minutes of rest, with automated measurements at 1 minute intervals : "un-attended", then "attended" * Hemodynamic parameters : * Sphygmocor® : measure of the central blood pressure and pulse wave velocity * MESI® tool : measure of the Systolic Pressure Index (PSI or IPS) * pOpmetre® : Calculation of the speed of the pulse wave by the pOpmetre® device * Others : if indicated (echocardiography, ABPM)

Sponsors & Collaborators

  • URC-CIC Paris Descartes Necker Cochin

    collaborator OTHER

  • Assistance Publique - Hôpitaux de Paris

    lead OTHER

Principal Investigators

  • Lynda CHEDDANI, MD · Assistance Publique - Hôpitaux de Paris

Eligibility

Min Age
18 Years
Sex
ALL
Healthy Volunteers
No

Timeline & Regulatory

Start
2021-12-10
Primary Completion
2023-06-07
Completion
2023-07-07

Countries

  • France

Study Locations

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Entities

Diseases

Read the full study record

This page highlights key information. For complete eligibility criteria, study locations, investigator contacts, and the full protocol, visit the original record on ClinicalTrials.gov.

View NCT05114291 on ClinicalTrials.gov