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Interrupters of VAscular daMAge in Malignant Hypertension

NCT04991077 · Status: COMPLETED · Type: OBSERVATIONAL · Enrollment: 45

Last updated 2024-10-30

No results posted yet for this study

Summary

The pathophysiology of malignant hypertension is poorly understood. The objective of this translational research project is to evaluate the relationship between activation of vasoactive systems (renin-angiotensin and endothelin systems), angiogenic signal deficiency (VEGF and sFlt-1) and the occurrence of malignant hypertension episodes in humans.

Conditions

  • Malignant Hypertension

Interventions

BIOLOGICAL

analyse of angiogenic, vasoactive and VEGF systems

the angiogenic, vasoactive and VEGF systems will be analysed through blood and urine sampling. These samples will be collected at the time of malignant hypertension diagnosis and repeated one month later, in 30 patients (patients group). The same tests will be performed once in 15 patients with severe non-malignant hypertension, constituting the control group.

Sponsors & Collaborators

  • Centre Hospitalier de PAU

    lead OTHER

Eligibility

Min Age
18 Years
Sex
ALL
Healthy Volunteers
No

Timeline & Regulatory

Start
2022-02-07
Primary Completion
2024-10-11
Completion
2024-10-11

Countries

  • France

Study Locations

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Read the full study record

This page highlights key information. For complete eligibility criteria, study locations, investigator contacts, and the full protocol, visit the original record on ClinicalTrials.gov.

View NCT04991077 on ClinicalTrials.gov