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Brain Connectivity Patterns in Chronic Temporomandibular Joint Disorders

NCT05068908 · Status: RECRUITING · Type: OBSERVATIONAL · Enrollment: 95

Last updated 2025-09-08

No results posted yet for this study

Summary

This study addresses the timely problem of painful temporomandibular disorders (TMD), the most common cause of orofacial pain second only to tooth pain. Findings from previous studies suggest that dysregulation of connectivity within specific brain circuits is part of chronic pain pathophysiology. This study will identify connectivity patterns within those brain circuits as potential signatures for pain- related disability in chronic TMD pain participants. New knowledge regarding these brain connectivity patterns is expected to be significant because it will support improved phenotyping of this heterogeneous participant population. It is also expected that this finding can potentially be extrapolated to other chronic pain conditions, such as back pain, migraine headache, and fibromyalgia that are frequently comorbid conditions in chronic TMD participants.

Conditions

  • Chronic Pain
  • Temporomandibular Joint Disorders
  • Temporomandibular Joint Pain

Sponsors & Collaborators

Principal Investigators

  • Estephan J Moana-Filho, DDS, MS, PhD · University of Minnesota

Eligibility

Min Age
18 Years
Max Age
65 Years
Sex
FEMALE
Healthy Volunteers
Yes

Timeline & Regulatory

Start
2022-03-02
Primary Completion
2026-08-31
Completion
2026-08-31

Countries

  • United States

Study Locations

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Entities

Diseases
Companies

Read the full study record

This page highlights key information. For complete eligibility criteria, study locations, investigator contacts, and the full protocol, visit the original record on ClinicalTrials.gov.

View NCT05068908 on ClinicalTrials.gov