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Correlation Between Cycle Threshold (Ct) Values in COVID-19, Health Status and Laboratory Biomarkers in the Population of Medellin- Colombia Evaluated in a Specialized Laboratory.

NCT05067920 · Status: UNKNOWN · Type: OBSERVATIONAL · Enrollment: 120

Last updated 2021-12-28

No results posted yet for this study

Summary

This study will evaluate the correlation between the symptomaticity, Ct value, laboratory biomarkers associated to COVID-19 and the disease progression in hospitalized patients and outpatients with SARS-CoV2 infection diagnosed by RT-PCR assay for nasopharyngeal swab specimens in a specialized laboratory at Medellin,Colombia.

Conditions

  • Covid19

Interventions

DIAGNOSTIC_TEST

Levels of SARS-COV-2 antibodies

Study of the SARS-COV-2 antibodies of COVID-19 IgM ( day 5th and 14th) and IgG ( day 14th and 28th)

DIAGNOSTIC_TEST

rRT-PCR SARS-Cov-2

Real time RT-PCR for COVID-19 diagnosis at day 5th,14th and 28th

DIAGNOSTIC_TEST

Hematological and immunological biomarkers

Laboratory data measure at day 5th,14th and 28th: Hemogram, cytokine levels, ratio of CD4 + / CD8 + lymphocytes, and levels of dehydrogenase lactate, ferritin, D-dimer.

DIAGNOSTIC_TEST

Mitochondrial DNA

One time quantification mitochondrial DNA haplogroup.

DIAGNOSTIC_TEST

SARS-CoV-2 Viral Culturing

Probability of isolating SARS-Cov-2 in cell culture related to CT value above 32.

DIAGNOSTIC_TEST

Sequencing COVID-19

Sequencing viral protein spike (S) COVID-19 related to CT value below 15.

Sponsors & Collaborators

  • Laboratorio departamental de salud publica de Antioquia

    collaborator UNKNOWN

  • Sistema general de regalias (BPIN 2020000100152)

    collaborator UNKNOWN

  • Universidad de Antioquia

    lead OTHER

Principal Investigators

  • Andres F Zuluaga, MD, MSc, MeH · Universidad de Antioquia

Eligibility

Min Age
18 Years
Max Age
99 Years
Sex
ALL
Healthy Volunteers
No

Timeline & Regulatory

Start
2021-09-27
Primary Completion
2022-01-30
Completion
2022-01-31

Countries

  • Colombia

Study Locations

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Read the full study record

This page highlights key information. For complete eligibility criteria, study locations, investigator contacts, and the full protocol, visit the original record on ClinicalTrials.gov.

View NCT05067920 on ClinicalTrials.gov