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The Roles of Gut Microbiome in UTI Susceptible Women

NCT05065008 · Status: ACTIVE_NOT_RECRUITING · Phase: NA · Type: INTERVENTIONAL · Enrollment: 160

Last updated 2025-09-05

No results posted yet for this study

Summary

Clinical trials on cranberry juice and UTI prevention yielded both positive and negative results for unknown reason. Gut microbiome in women affect the absorption and metabolism of cranberry bioactives. The variation of gut microbiome is a probable mechanism for metabolic polymorphisms and disparity in UTI prevention in women.

Conditions

  • Healthy

Interventions

OTHER

Cranberry juice

The responders and non-responders will drink 20-30 oz of (590-885 mL) 27% cranberry juice daily for 3 weeks.

OTHER

Apple juice

The participants will drink apple juice with matching sugar content and calories for 3 weeks

Sponsors & Collaborators

  • United States Department of Agriculture (USDA)

    collaborator FED

  • University of Florida

    lead OTHER

Principal Investigators

  • Liwei Gu, PhD · University of Florida

  • Gary P Wang, PhD · University of Florida

Study Design

Allocation
RANDOMIZED
Purpose
TREATMENT
Masking
NONE
Model
CROSSOVER

Eligibility

Min Age
21 Years
Max Age
65 Years
Sex
FEMALE
Healthy Volunteers
Yes

Timeline & Regulatory

Start
2021-10-18
Primary Completion
2026-08-31
Completion
2026-08-31

Countries

  • United States

Study Locations

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Read the full study record

This page highlights key information. For complete eligibility criteria, study locations, investigator contacts, and the full protocol, visit the original record on ClinicalTrials.gov.

View NCT05065008 on ClinicalTrials.gov