Cranberry Proanthocyanidins for Modification of Intestinal E. Coli Flora and Prevention of Urinary Tract Infections in UTI-Susceptible Women

Summary

The purpose of the research is to determine if eating sweetened, dried cranberries or strawberry fruit pieces will increase the types of different E. coli bacteria in the intestines which may reduce the likelihood of a major, or highly harmful urinary type of bacteria which cause urinary tract infections in susceptible women.

Conditions

• Urinary Tract Infection

Interventions

OTHER

Sweetened, dried cranberries

Women in Arm 1 will consume one serving (1/3 cup; 42 g) of sweetened, dried cranberries each day for two weeks.

OTHER

Strawberry Fruit Pieces

1 serving (1/3 cup; 42 g) of strawberry fruit pieces each day for three separate, two-week periods. Each two week period will be separated by a two-week interval.

OTHER

Sweetened, dried cranberries

1 serving (1/3 cup; 42 g) of sweetened, dried cranberries each day for three separate, two-week periods. Each two week period will be separated by a two-week interval.

OTHER

Sweetened, dried cranberries

1 serving (1/3 cup; 42 g) of sweetened, dried cranberries each day for one 4-week period.

OTHER

Strawberry Fruit Pieces

1 serving (1/3 cup; 42 g) of strawberry fruit pieces each day for one 4-week period.

OTHER

Observation

Subjects in the non-UTI susceptible group will have one visit where one vaginal and one rectal swab will be collected.

Sponsors & Collaborators

• Ocean Spray Cranberries, Inc.

  collaborator INDUSTRY

• University of Wisconsin, Madison

  lead OTHER

Principal Investigators

• Walter Hopkins, PhD · University of Wisconsin, Madison

Study Design

Allocation

RANDOMIZED

Purpose

BASIC_SCIENCE

Masking

SINGLE

Model

SINGLE_GROUP

Eligibility

Min Age

18 Years

Max Age

65 Years

Sex

FEMALE

Healthy Volunteers

Yes

Timeline & Regulatory

Start

2010-09-30

Primary Completion

2012-09-30

Completion

2012-09-30

Countries

• United States

Study Locations