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Temperature and Bicarbonate: Hemodynamic Effects During Dialysis

NCT05052151 · Status: COMPLETED · Phase: NA · Type: INTERVENTIONAL · Enrollment: 16

Last updated 2022-05-18

No results posted yet for this study

Summary

To elucidate the role of dialysate temperature and bicarbonate on hemodynamic parameters, plasma pH and electrolytes that potentially mediate this effect, the investigators wish to conduct a single-blinded, randomized, controlled, crossover study, specifically examining the effects of

* A fixed low temperature dialysate of 35°C compared to a fixed dialysate temperature of 37°C.
* A low dialysate bicarbonate concentration of 30 mmol/L compared to a high dialysate bicarbonate concentration of 38 mmol/L.

Conditions

  • End Stage Renal Disease on Dialysis

Interventions

OTHER

Low dialysate temperature

35°C

OTHER

High dialysate temperature

37°C

OTHER

Low dialysate bicarbonate concentration

30 mmol/L

OTHER

High dialysate bicarbonate concentration

38 mmol/L

Sponsors & Collaborators

  • University of Aarhus

    lead OTHER

Principal Investigators

  • Niels H Buus, Professor · Department of Renal Medicine, Aarhus University Hospital

  • Jens D Jensen, MD, PhD · Department of Renal Medicine, Aarhus University Hospital

  • Ina H Jørgensen, Student · Department of Renal Medicine, Aarhus University Hospital

  • Jonas SK Jensen, Student · Department of Renal Medicine, Aarhus University Hospital

  • Christian D Peters, MD, PhD · Department of Renal Medicine, Aarhus University Hospital

Study Design

Allocation
RANDOMIZED
Purpose
TREATMENT
Masking
SINGLE
Model
CROSSOVER

Eligibility

Min Age
18 Years
Sex
ALL
Healthy Volunteers
No

Timeline & Regulatory

Start
2021-08-25
Primary Completion
2021-12-20
Completion
2022-01-03

Countries

  • Denmark

Study Locations

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Read the full study record

This page highlights key information. For complete eligibility criteria, study locations, investigator contacts, and the full protocol, visit the original record on ClinicalTrials.gov.

View NCT05052151 on ClinicalTrials.gov