MedTrace Logo

The Effect of Bicarbonate Profiling in Dialysis Fluid on Phosphate Removal During Hemodialysis and Blood pH

NCT05861700 · Status: COMPLETED · Phase: NA · Type: INTERVENTIONAL · Enrollment: 20

Last updated 2023-05-23

No results posted yet for this study

Summary

Hyperphosphatemia is still an unresolved problem among hemodialysis patients and significantly increases the risk of death from cardiovascular diseases. Research to date has not answered the question of whether dialysate bicarbonate concentration profiling can improve phosphate removal and its concentration without negative impact on the acid-base balance. This study addressed this issue.

Twenty stable hemodialysis patients will enroll to a four-week study during which different dialysate bicarbonate concentration profiles will be used each week. Each patient will undergo the following profiles (one-week periods): Treatment A - stable dialysate bicarbonate concentration Dbic 35 mmol/L during the whole HD session, Treatment B - Dbic 35 mmol/L for the first two hours and Dbic 30 mmol/L for the next two hours and Treatment C - the opposite mid-HD change Dbic from 30 to 35 mmol/L and one week wash-out period between Treatment B and C. We will collect blood samples each hour during the session and one hour after HD completion.

Conditions

  • Phosphorus Metabolism Disorders
  • Acid-Base Balance Disorder

Interventions

OTHER

Group 1: B) Dbic 35 -30 mmol/L C) Dbic 30- 35 mmol/L

A change Dbic in a middle of hemodialysis

OTHER

Group 2: C) Dbic 30 -35 mmol/L B) Dbic 35- 30 mmol/L

A change Dbic in a middle of hemodialysis

Sponsors & Collaborators

  • University of Warsaw

    collaborator OTHER

  • Polish Academy of Sciences

    collaborator OTHER

  • Medical University of Warsaw

    lead OTHER

Study Design

Allocation
NON_RANDOMIZED
Purpose
TREATMENT
Masking
NONE
Model
SINGLE_GROUP

Eligibility

Min Age
18 Years
Sex
ALL
Healthy Volunteers
No

Timeline & Regulatory

Start
2018-05-21
Primary Completion
2020-12-31
Completion
2022-08-31

Countries

  • Poland

Study Locations

More Related Trials

Read the full study record

This page highlights key information. For complete eligibility criteria, study locations, investigator contacts, and the full protocol, visit the original record on ClinicalTrials.gov.

View NCT05861700 on ClinicalTrials.gov