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Evaluation of Efficacy of Comprehensive Genomic Tumour Profiling (CGP) From Liquid and/or Tissue Biopsy in Patients With Locally Advanced and/or Metastatic Solid Cancer

NCT05032092 · Status: ACTIVE_NOT_RECRUITING · Phase: NA · Type: INTERVENTIONAL · Enrollment: 235

Last updated 2025-11-21

No results posted yet for this study

Summary

The aims of this study are

* to evaluate the efficacy of comprehensive genomic tumour profiling (CGP) from liquid and/or tissue biopsy in patients with locally advanced and/or metastatic solid cancer.
* to evaluate and describe the impact of treatment decisions based on CGP on individual progression free survival in patients with locally advanced and/or metastatic solid cancer
* to evaluate and describe similarities and differences between the treatment suggestions based on CGP/IHC (immuno-histochemistry) of tissue biopsy and liquid biopsy.

In patients with locally advanced and/or metastatic carcinoma the primary efficacy objective of the study is, to observe and describe the PFS (progression-free survival) of the matched treatment compared to the PFS of the most recent therapy.

Conditions

Interventions

DIAGNOSTIC_TEST

Next Generation Sequencing

Molecular analysis of liquid biopsy.

DIAGNOSTIC_TEST

Next Generation Sequencing

Molecular analysis of tissue biopsy.

GENETIC

Biomarker Monitoring

Biomarker Monitoring of study patients receiving matched therapy.

Sponsors & Collaborators

  • Medical University of Graz

    lead OTHER

Principal Investigators

  • Philipp Jost, Univ.Prof.Dr.MD, · Medical University of Graz, Department of Internal Medicine, Division of Clinical Oncology

  • Armin Gerger, Univ.Prof.,MD. · Medical University of Graz, Department of Internal Medicine, Division of Clinical Oncology

Study Design

Allocation
NA
Purpose
DIAGNOSTIC
Masking
NONE
Model
SINGLE_GROUP

Eligibility

Min Age
18 Years
Sex
ALL
Healthy Volunteers
No

Timeline & Regulatory

Start
2021-11-24
Primary Completion
2025-12-31
Completion
2027-12-31

Countries

  • Austria

Study Locations

More Related Trials

Entities

Diseases

Read the full study record

This page highlights key information. For complete eligibility criteria, study locations, investigator contacts, and the full protocol, visit the original record on ClinicalTrials.gov.

View NCT05032092 on ClinicalTrials.gov