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Examining Blood and Tissue Samples to Identify Diagnostic Markers in Patients With Metastatic Cancer Undergoing Tumor Removal

NCT05530759 · Status: RECRUITING · Type: OBSERVATIONAL · Enrollment: 50

Last updated 2025-04-02

No results posted yet for this study

Summary

This study characterizes deoxyribonucleic acid (DNA) and proteomic (protein) changes in both biopsies and tumors removed during surgery of patients who have been diagnosed with aggressive/metastatic (that has spread to other places in the body) cancer in order to identify possible diagnostic markers and potential drugs for treating aggressive tumor types. Proteomic analyses include looking at the proteome, or all the proteins expressed, or made by DNA at a specific moment in time. Studying samples of blood, buccal (cheek), and tissue in the laboratory from patients undergoing surgical resection or biopsy may help doctors learn more about the changes that occur in the proteome, DNA alterations, and identify molecular biomarkers for which therapeutic drugs may exist. Studying the DNA in tumor tissue and in blood may also help researchers see if the tumor has important differences.

Conditions

  • Hematopoietic and Lymphoid System Neoplasm
  • Metastatic Malignant Solid Neoplasm

Interventions

PROCEDURE

Biopsy Specimen

Undergo collection of tissue samples

PROCEDURE

Biospecimen Collection

Undergo collection of blood and buccal swab samples

PROCEDURE

Biospecimen Collection

Undergo collection of archived tissue and blood samples

OTHER

Medical Chart Review

Review of medical record

Sponsors & Collaborators

Principal Investigators

  • Aaron S. Mansfield, M.D. · Mayo Clinic in Rochester

Eligibility

Min Age
18 Years
Sex
ALL
Healthy Volunteers
No

Timeline & Regulatory

Start
2022-06-29
Primary Completion
2027-04-07
Completion
2028-04-07

Countries

  • United States

Study Locations

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Entities

Companies

Read the full study record

This page highlights key information. For complete eligibility criteria, study locations, investigator contacts, and the full protocol, visit the original record on ClinicalTrials.gov.

View NCT05530759 on ClinicalTrials.gov