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Effect of Different Sedation and Analgesia Strategies on Patients With Mechanical Ventilation

NCT05024799 · Status: UNKNOWN · Phase: PHASE4 · Type: INTERVENTIONAL · Enrollment: 300

Last updated 2021-08-27

No results posted yet for this study

Summary

Most patients in ICU are treated with a combination of analgesics and sedatives in most cases. Due to the different mechanism of different sedative and analgesic drugs, different antagonistic or synergistic effects may occur when combined with drugs, resulting in different clinical effects, especially significant effects on ventilators for patients with assisted breathing. Therefore, this study hopes to compare the effects of different sedative and analgesic drug combinations on the duration of mechanical ventilation for patients with ventilators, so as to guide the clinical adoption of a more reasonable sedative and analgesic scheme.

Conditions

  • Respiratory Insufficiency

Interventions

DRUG

Fentanyl, propofol

The patients in this group will be administered with fentanyl and propofol

DRUG

fentanyl and dexmedetomindine

The patients in this group will be administered with fentanyl and dexmedetomindine

DRUG

Butorphanol and propofol

The patients in this group will be administered with butorphanol and propofol

DRUG

Butorphanol and dexmedetomindine

The patients in this group will be administered with butorphanol and dexmedetomindine

Sponsors & Collaborators

  • The Affiliated Hospital of Qingdao University

    lead OTHER

Study Design

Allocation
RANDOMIZED
Purpose
TREATMENT
Masking
TRIPLE
Model
PARALLEL

Eligibility

Min Age
18 Years
Sex
ALL
Healthy Volunteers
No

Timeline & Regulatory

Start
2022-01-31
Primary Completion
2024-12-31
Completion
2024-12-31

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Read the full study record

This page highlights key information. For complete eligibility criteria, study locations, investigator contacts, and the full protocol, visit the original record on ClinicalTrials.gov.

View NCT05024799 on ClinicalTrials.gov