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Neuropathological Changes of the Intestinal Wall in Patients With Bowel Evacuation Disorders

NCT05016700 · Status: RECRUITING · Type: OBSERVATIONAL · Enrollment: 500

Last updated 2025-03-10

No results posted yet for this study

Summary

Constipation and defecation disorders affect about 15% of the European population and of those up to 30% of the patients over 65 years of age. For those affected, this is associated with major restrictions in quality of life and high health care costs .

The underlying causes of constipation and defecation are complex and only partially understood.

Intestinal (full wall) resections taken in clinical practice from these patients when conservative therapy has been exhausted show rarefaction of ganglion cell nests in the myenteric plexus and submucosal plexus as well as changes in cholinergic innervation.

Initial histopathological investigations suggest an inflammatory genesis of this rarefaction of ganglion cell nests, which will be further characterised/investigated in the context of this study on the basis of further histopathological and serological investigations. This may lead to novel therapeutic approaches that can causally treat the symptoms of those affected.

Conditions

Interventions

DIAGNOSTIC_TEST

blood sample

we want to identify a diagnostic option to identify patients, who have a neuropathological distraction of their ganglia cells in the bowel

Sponsors & Collaborators

  • University of Cologne

    collaborator OTHER

  • Evangelisches Klinikum Köln Weyertal gGmbH

    lead OTHER

Principal Investigators

  • Claudia Rudroff, MD · Claudia Rudroff, MD PhD

Eligibility

Min Age
18 Years
Sex
ALL
Healthy Volunteers
No

Timeline & Regulatory

Start
2019-03-20
Primary Completion
2030-12-31
Completion
2033-12-31

Countries

  • Germany

Study Locations

More Related Trials

Entities

Diseases

Read the full study record

This page highlights key information. For complete eligibility criteria, study locations, investigator contacts, and the full protocol, visit the original record on ClinicalTrials.gov.

View NCT05016700 on ClinicalTrials.gov