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Training in Ataxia - Individuals With Degenerative Cerebellar Diseases

NCT05002218 · Status: COMPLETED · Phase: NA · Type: INTERVENTIONAL · Enrollment: 64

Last updated 2025-11-04

Study results available
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Summary

Balance and aerobic training show promise as treatments for degenerative cerebellar diseases, but the neural effects of both training methods are unknown. The goal of this project is to evaluate how each training method impacts the brain, and particularly, the degenerating cerebellum. Various neuroimaging techniques will be used to accomplish this goal and test the hypothesis that balance training impacts brain structures outside the cerebellum whereas aerobic training causes more neuroplastic changes within the cerebellum.

Conditions

  • Cerebellar Ataxia

Interventions

BEHAVIORAL

Aerobic Training

Aerobic training on stationary bike 5x a week for 30 minutes a day.

BEHAVIORAL

Balance Training

Balance training 5x a week for 30 minutes as instructed by a therapist. Standard of care.

Sponsors & Collaborators

  • National Institute of Neurological Disorders and Stroke (NINDS)

    collaborator NIH

  • Columbia University

    lead OTHER

Principal Investigators

  • Scott M Barbuto, MD · Assistant Professor of Rehabilitation and Regenerative Medicine

Study Design

Allocation
RANDOMIZED
Purpose
TREATMENT
Masking
DOUBLE
Model
PARALLEL

Eligibility

Min Age
18 Years
Sex
ALL
Healthy Volunteers
No

Timeline & Regulatory

Start
2022-01-31
Primary Completion
2024-11-06
Completion
2024-11-06

Countries

  • United States

Study Locations

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Entities

Companies

Read the full study record

This page highlights key information. For complete eligibility criteria, study locations, investigator contacts, and the full protocol, visit the original record on ClinicalTrials.gov.

View NCT05002218 on ClinicalTrials.gov