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Diagnostic Potential of UCHL1 in Acute Decompensated Heart Failure

NCT04999995 · Status: COMPLETED · Type: OBSERVATIONAL · Enrollment: 17

Last updated 2025-08-12

No results posted yet for this study

Summary

Autophagy is considered an important component of Heart failure progression. Deubiquitination enzymes play an important role in autophagy. An important regulatory process within the autophagy pathway is ubiquitination. Ubiquitination targets proteins for degradation. On the contrary, de-ubiquitinating proteins (such as UCHL1) reverses this process. Studies have demonstrated deubiquitination to be linked to certain pathological processes, such as heart failure. UCHL1 will be examined as a potential marker of disease progression in acute decompensated heart failure.

Conditions

Sponsors & Collaborators

  • William Jennings Bryan Dorn VA Medical Center

    collaborator FED

  • VA Office of Research and Development

    lead FED

Principal Investigators

  • Taixing Cui, PhD MB · Wm. Jennings Bryan Dorn VA Medical Center, Columbia, SC

Eligibility

Min Age
18 Years
Sex
ALL
Healthy Volunteers
No

Timeline & Regulatory

Start
2021-06-01
Primary Completion
2025-03-17
Completion
2025-03-17

Countries

  • United States

Study Locations

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Entities

Diseases

Read the full study record

This page highlights key information. For complete eligibility criteria, study locations, investigator contacts, and the full protocol, visit the original record on ClinicalTrials.gov.

View NCT04999995 on ClinicalTrials.gov