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Evaluation of Lung T1-MRI in Pediatric Cystic Fibrosis Patients

NCT04994301 · Status: COMPLETED · Type: OBSERVATIONAL · Enrollment: 56

Last updated 2025-02-27

No results posted yet for this study

Summary

In this observational study, the investigators evaluate the sensitivity of T1-MRI to identify lung perfusion changes in pediatric patients with CF (age = 6-11) before and after initiating FDA-approved Trikafta therapy. The investigators compare these Lung T1 MRI assessments (% Normal lung perfusion) to currently best-available assessments of lung function in CF patients (i.e., MBW (LCI( and Spirometry (FEV1 % Predicted).

Conditions

Interventions

DIAGNOSTIC_TEST

Lung T1 MRI

Evaluation of lung T1 MRI to Assess Lung Disease

Sponsors & Collaborators

  • University Hospitals Cleveland Medical Center

    lead OTHER

Principal Investigators

  • Chris Flask, PhD · Case Western Reserve University

Eligibility

Min Age
5 Years
Max Age
11 Years
Sex
ALL
Healthy Volunteers
No

Timeline & Regulatory

Start
2020-12-15
Primary Completion
2023-12-15
Completion
2023-12-15

Countries

  • United States

Study Locations

More Related Trials

Entities

Diseases

Read the full study record

This page highlights key information. For complete eligibility criteria, study locations, investigator contacts, and the full protocol, visit the original record on ClinicalTrials.gov.

View NCT04994301 on ClinicalTrials.gov