Investigation of Relationship Between Vascular Functions, Exercise Capacity, and Respiratory Functions in CF

Summary

In the literature, there is no study that evaluates the endothelial function and arterial stiffness together and investigates its relationship with exercise capacity and respiratory functions in children with CF of different obstruction severities. Therefore, the aim of this study is to investigate and compare microvascular (endothelium), macrovascular (arterial stiffness) functions in children with CF of different obstruction severities, and to investigate the relationship between micro and macrovascular functions and exercise capacity and respiratory functions in children with CF of different obstruction severities.

Conditions

• Cystic Fibrosis

Interventions

OTHER

Maximal exercise test

The maximal exercise test will be performed on an electronically braked bicycle ergometer.

OTHER

Endothelial dysfunction assessment

Endothelial dysfunction will be determined by blood samples. Blood samples will be collected and analyzed for the responses of ICAM-1, VCAM-1, E-Selectin, VEGF, ET-1.

OTHER

Arterial stiffness assessment

Arterial stiffness, oscillometric pulse wave velocity (PWV) and augmentation index will be evaluated by recorded brachial pulse waves with automatically with the oscillometric device.

Sponsors & Collaborators

• Hacettepe University

  lead OTHER

Principal Investigators

• Deniz Inal-Ince, PhD · Hacettepe University

• Senem Simsek, MSc · Hacettepe University

• Elmas Ebru Gunes-Yalcin, PhD · Hacettepe University

• Murat Timur Budak, PhD · Hacettepe University

• Nagehan Emiralioglu, PhD · Hacettepe University

• Aslihan Cakmak, MSc · Hacettepe University

• Yasemin Kartal, MSc · Hacettepe University

• Suna Sabuncuoğlu, PhD · Hacettepe University

• Meltem Akgül Erdal, MSc · Hacettepe University

Eligibility

Min Age

10 Years

Max Age

18 Years

Sex

ALL

Healthy Volunteers

No

Timeline & Regulatory

Start

2022-04-11

Primary Completion

2022-12-08

Completion

2023-05-02

Countries

• Turkey (Türkiye)

Study Locations