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GWICTIC: NAC Mechanistic Study in Gulf War Veterans

NCT04987775 · Status: RECRUITING · Phase: EARLY_PHASE1 · Type: INTERVENTIONAL · Enrollment: 170

Last updated 2025-07-08

No results posted yet for this study

Summary

This mechanistic study will test if NAC affects chronic oxidative stress and depletion of antioxidants in GWI participants. Blood specimen collection and neuroimaging will be used to determine whether NAC affects serum glutathione (GSH) concentration and oxidative stress in the CNS when compared to placebo.

Conditions

  • Gulf War Syndrome

Interventions

DRUG

N-Acetyl Cysteine

900mg 2x daily

DRUG

Placebo

Matching placebo bid

Sponsors & Collaborators

  • RTI International

    collaborator OTHER

  • Boston University

    collaborator OTHER

  • Weill Medical College of Cornell University

    collaborator OTHER

  • Nova Southeastern University

    lead OTHER

Principal Investigators

  • Nancy Klimas, MD · Nova Southeastern Univeristy

Study Design

Allocation
RANDOMIZED
Purpose
TREATMENT
Masking
TRIPLE
Model
PARALLEL

Eligibility

Min Age
47 Years
Max Age
70 Years
Sex
ALL
Healthy Volunteers
No

Timeline & Regulatory

Start
2023-11-30
Primary Completion
2026-04-30
Completion
2026-04-30

Countries

  • United States

Study Locations

More Related Trials

Entities

Drugs

Read the full study record

This page highlights key information. For complete eligibility criteria, study locations, investigator contacts, and the full protocol, visit the original record on ClinicalTrials.gov.

View NCT04987775 on ClinicalTrials.gov