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Therapeutic Plasma Exchange Followed by Convalescent Plasma Transfusion in Severe and Critically Ill COVID-19 Patients

NCT04973488 · Status: COMPLETED · Phase: NA · Type: INTERVENTIONAL · Enrollment: 38

Last updated 2024-08-26

Study results available
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Summary

Therapeutic plasma exchange (TPE) has been proposed as a rescue therapy in critically ill COVID-19 patients. The aim of this study is to determine whether combining TPE with convalescent plasma (CVP) transfusion early during the intensive care unit (ICU) stay, improves survival among this heterogeneous population.

Conditions

  • COVID-19 Pneumonia
  • COVID-19 Respiratory Infection
  • Acute Respiratory Failure
  • Acute Respiratory Distress Syndrome

Interventions

OTHER

Therapeutic plasma exchange

The intervention is a combination between the procedure of Therapeutic plasma exchange and biological transfusion of convalescent plasma from donors that have have COVID-19

Sponsors & Collaborators

  • University of Medicine and Pharmacy "Victor Babes" Timisoara

    collaborator OTHER

  • Novacescu Alexandru

    lead OTHER

Principal Investigators

  • Monica Licker, MD, PhD · University of Medicine and Pharmacy "Victor Babes" Timisoara

Study Design

Allocation
NON_RANDOMIZED
Purpose
TREATMENT
Masking
DOUBLE
Model
PARALLEL

Eligibility

Min Age
18 Years
Max Age
90 Years
Sex
ALL
Healthy Volunteers
No

Timeline & Regulatory

Start
2020-07-25
Primary Completion
2021-01-10
Completion
2021-01-10

Countries

  • Romania

Study Locations

More Related Trials

Entities

Diseases

Read the full study record

This page highlights key information. For complete eligibility criteria, study locations, investigator contacts, and the full protocol, visit the original record on ClinicalTrials.gov.

View NCT04973488 on ClinicalTrials.gov