MedTrace Logo

Understanding the Role of Oral Microbiota in Behçet's Disease (BEHCETBIOT)

NCT04959435 · Status: COMPLETED · Type: OBSERVATIONAL · Enrollment: 66

Last updated 2024-09-19

No results posted yet for this study

Summary

Behçet's disease (BD) is a systemic vasculitis that affects, especially, young people.

Although its etiology remains unexplained, data suggest that the inflammatory response during BD results from a disruption of the homeostasis of innate and adaptive immune responses in genetically predisposed people. The microbiota could play a triggering role in BD, in particular the salivary and dental plaque microbiota. The aim of the Behçetbiot study is therefore to establish microbial profiles of dental plaque, pathological (on the mouth ulcer) and non-pathological mucous membrane, salivary and digestive and to compare them with control subjects not suffering from BD, related to the first degree, of the same socio-cultural level and to determine whether dysbiosis is correlated with a local and systemic pro-inflammatory response, by measuring salivary level of pro-inflammatory cytokines and blood level of CRP, fibrinogen, orosomucoïd and haptoglobin, and to compare them with controls.

Conditions

  • Behçet Disease
  • Physiopathology
  • Microbiota
  • Oral Microbiota

Interventions

OTHER

biological samples collection

samples of blood, faeces, saliva, dental plaque, oral mucosa, genital mucosa

Sponsors & Collaborators

  • University Hospital, Clermont-Ferrand

    lead OTHER

Principal Investigators

  • Marc André · University Hospital, Clermont-Ferrand

Eligibility

Min Age
18 Years
Max Age
55 Years
Sex
ALL
Healthy Volunteers
No

Timeline & Regulatory

Start
2022-01-10
Primary Completion
2024-06-21
Completion
2024-06-21

Countries

  • France

Study Locations

More Related Trials

Read the full study record

This page highlights key information. For complete eligibility criteria, study locations, investigator contacts, and the full protocol, visit the original record on ClinicalTrials.gov.

View NCT04959435 on ClinicalTrials.gov