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Circulating Anti-Beta2-glycoprotein Antibodies and Endothelial Dysfunction

NCT01822990 · Status: COMPLETED · Type: OBSERVATIONAL · Enrollment: 60

Last updated 2013-04-04

No results posted yet for this study

Summary

Circulating anti-beta2-glycoprotein antibodies have been associated with coronary artery disease and peripheral arterial disease. This auto-antibodies could activate endothelial cells leading to the expression of leukocyte adhesion molecules and increasing the release of pro-inflammatory cytokines.

On the other hand, endothelial dysfunction of atherosclerotic patients acts as a primary pathogenic event, as it occur before structural changes are evident on angiogram or ultrasound scan. Loss of endothelial normal function causes vasoconstriction, local coagulation alterations and an increase arterial wall proliferation. This situation s been attributed to a reduction in nitric oxide bioactivity, and to an increase oxygen-free radical formation in the context of the pro-inflammatory status found in atherosclerosis.

Hypothesis: Circulating Anti-beta2-glycoprotein I antibodies could be associated with endothelial dysfunction and nitric oxide metabolism disruption en patients with peripheral arterial disease.

Conditions

  • Peripheral Arterial Disease

Sponsors & Collaborators

  • Hospital Universitario Getafe

    lead OTHER

Principal Investigators

  • Cesar Varela, MD · Hospital Universitario de Getafe

  • Joaquin De Haro, MD · Hospital Universitario de Getafe

  • Francisco Acin, MD, PhD · Hospital Universitario de Getafe

Eligibility

Min Age
18 Years
Max Age
90 Years
Sex
MALE
Healthy Volunteers
Yes

Timeline & Regulatory

Start
2011-02-28
Primary Completion
2012-07-31
Completion
2012-07-31

Countries

  • Spain

Study Locations

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Read the full study record

This page highlights key information. For complete eligibility criteria, study locations, investigator contacts, and the full protocol, visit the original record on ClinicalTrials.gov.

View NCT01822990 on ClinicalTrials.gov