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The Effectiveness of Hyperpure Chlorine Dioxide and Sodium Hypochlorite Irrigants in Endodontic Retreament in RCT

NCT04954638 · Status: UNKNOWN · Type: OBSERVATIONAL · Enrollment: 40

Last updated 2022-10-31

No results posted yet for this study

Summary

Endodontic treatment aims to eliminate pathogenic microbes from the root canal. Hyperpure chlorine dioxide is an endodontic irrigant. Our goal is to compare the efficacy of hyperpure chlorine dioxide with the gold standard sodium hypochlorite in the non-surgical retreatment of root canal treated teeth with chronic periapical lesions in a randomized clinical trial. Forty patients having chronic apical periodontitis will randomly be chosen for the study from the patients attending our Department of Conservative Dentistry. Endodontic treatment will be done according to professional quidelines. The patients will randomly be divided into two groups. In the first (control) group sodium hypochlorite, in the second group hyperpure chlorine dioxide will be used as desinfectant. The first sample will be taken from the root canal after removing the previous root canal obturation prior to desinfection. The second sample will be taken one week after temporization. The samples will be evaluated by culturing, MALDI-ToF and PCR strip test. After root canal obturation the the periapical status will be followed by clinical evaluation and control x-rays.

Conditions

  • Persistent Infection
  • Periapical Lesion

Interventions

OTHER

endodontic desinfection

* outcome assessment of the retreatment of endodontically treated teeth presenting chronic apical periodontitis * effectiveness of hyperpure chlorine dioxide compared with sodium hypochloride * using microbiological methods * outcome assessed by radiological method and clinical evaluation

Sponsors & Collaborators

  • Eniko Vaszine Szabo

    lead OTHER

Principal Investigators

  • Enikő Vasziné Szabó, DMD PhD · Semmelweis University

  • Zsolt Lohinai, DMD PhD · Semmelweis University

Eligibility

Min Age
18 Years
Max Age
65 Years
Sex
ALL
Healthy Volunteers
No

Timeline & Regulatory

Start
2019-11-15
Primary Completion
2023-07-31
Completion
2025-07-31

Countries

  • Hungary

Study Locations

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Read the full study record

This page highlights key information. For complete eligibility criteria, study locations, investigator contacts, and the full protocol, visit the original record on ClinicalTrials.gov.

View NCT04954638 on ClinicalTrials.gov