Therapies for Recovery of Hand Function After Stroke

Summary

After a stroke, it is very common to lose the ability to open the affected hand. The purpose of this study is to compare the effects of three different therapies on recovery of hand function after stroke and determine if any one is better than the other.

Conditions

• Stroke
• Upper Extremity Paresis
• Hemiplegia

Interventions

DEVICE

Electrical Stimulator

An electrical stimulator will be used to deliver electrical current through surface electrodes to produce hand opening by making the paretic finger and thumb extensor muscles contract. The stimulator can be programmed to turn on and off in a repetitive cyclic fashion (i.e., cNMES) or be programmed to deliver stimulation with an intensity that corresponds to the opening of a glove instrumented with sensors and plugged into the stimulator (i.e., CCFES).

BEHAVIORAL

Occupational Therapy

Task practice that requires movement and use of the paretic hand under the guidance of a trained therapist.

Sponsors & Collaborators

• Kessler Foundation

  collaborator OTHER

• National Institutes of Health (NIH)

  collaborator NIH

• Eunice Kennedy Shriver National Institute of Child Health and Human Development (NICHD)

  collaborator NIH

• The Cleveland Clinic

  collaborator OTHER

• Johns Hopkins University

  collaborator OTHER

• Emory University

  collaborator OTHER

• MetroHealth Medical Center

  lead OTHER

Principal Investigators

• Jayme Knutson, PhD · MetroHealth Medical Center

Study Design

Allocation

RANDOMIZED

Purpose

TREATMENT

Masking

SINGLE

Model

PARALLEL

Eligibility

Min Age

21 Years

Max Age

90 Years

Sex

ALL

Healthy Volunteers

No

Timeline & Regulatory

Start

2019-02-15

Primary Completion

2024-10-16

Completion

2024-10-16

Countries

• United States

Study Locations