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Effect of Genetic Polymorphisms on Response to Beta Blocker Therapy in Egyptian Patients

NCT04900545 · Status: COMPLETED · Type: OBSERVATIONAL · Enrollment: 80

Last updated 2022-12-01

No results posted yet for this study

Summary

Beta-blockers represent a cornerstone for the treatment of coronary artery disease (CAD). Their protective effect is based on the negative inotropic and chronotropic features, which have been tested in a large number of randomized controlled trials, both in patients with myocardial infarction (MI) and in those with stable angina, demonstrating a reduction of adverse cardiovascular events, a relief of symptoms and a reduction of myocardial ischemia

However, considerable interpatient variability in response to β-blockers has been reported which indicates that a considerable proportion of β-blocker-treated patients do not achieve the warranted cardio protection with β- blockers. This highlights the importance of identifying biomarkers associated with variability in response to β-blockers to improve the current approach for β- blocker selection, which seems to be suboptimal.

This study aims to study the effect of polymorphism in adrenergic beta receptors on beta-blocker response in Egyptian patients.

Conditions

Sponsors & Collaborators

  • Mohamed Saleh Fayed

    lead OTHER

Principal Investigators

  • Nagwa A Sabry, PhD · Ains Shams university

  • Mohamed A Saleh, PhD · Ain Shams University

  • Amal A EL-Kholy, PhD · Ain Shams University

  • Mohamed S Fayed, Bsc · Ains Shams university

Eligibility

Min Age
18 Years
Max Age
75 Years
Sex
ALL
Healthy Volunteers
No

Timeline & Regulatory

Start
2021-05-05
Primary Completion
2021-05-25
Completion
2021-08-01

Countries

  • Egypt

Study Locations

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Entities

Diseases

Read the full study record

This page highlights key information. For complete eligibility criteria, study locations, investigator contacts, and the full protocol, visit the original record on ClinicalTrials.gov.

View NCT04900545 on ClinicalTrials.gov