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SH-SS and GSH-GSSG Homeostasis in Post-stroke Patients

NCT04884555 · Status: COMPLETED · Type: OBSERVATIONAL · Enrollment: 77

Last updated 2021-05-13

No results posted yet for this study

Summary

In patients undergoing physical therapy after stroke, extracellular thiol-disulfide balance and intracellular oxidized-reduced glutathione balance levels will be monitored. The main objectives of this study are; (1) to determine the differences between thiol-disulfide and GSH-GSSG balances in stroke patients compared to healthy volunteers, (2) to evaluate the relationship of these balances with the severity of stroke, (3) to determine the predictive value of the levels of these balances on clinical prognosis and functional recovery outcomes, and (4) to investigate and to examine the effects of the physical therapy process on these parameters and functional recovery and their relationship with each other.

Conditions

Interventions

OTHER

Standard neurorehabilitation

Routine post-stroke rehabilitation

DIAGNOSTIC_TEST

Thiol-Disulphide Homeostasis

Monitoring the levels of thiol and disulphide in serum

DIAGNOSTIC_TEST

Oxidized-reduced Glutathione Homeostasis

Monitoring the levels of intracellular oxidized glutathione and reduced glutathione in whole blood samples

Sponsors & Collaborators

  • Abant Izzet Baysal University

    lead OTHER

Principal Investigators

  • Tugba Alisik, MD · Abant Izzet Baysal University

Eligibility

Min Age
18 Years
Sex
ALL
Healthy Volunteers
Yes

Timeline & Regulatory

Start
2020-07-01
Primary Completion
2021-01-01
Completion
2021-01-31

Countries

  • Turkey (Türkiye)

Study Locations

More Related Trials

Entities

Diseases

Read the full study record

This page highlights key information. For complete eligibility criteria, study locations, investigator contacts, and the full protocol, visit the original record on ClinicalTrials.gov.

View NCT04884555 on ClinicalTrials.gov