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Are Diabetics Type 2 More Prone to Dental Caries?

NCT04883086 · Status: COMPLETED · Type: OBSERVATIONAL · Enrollment: 182

Last updated 2022-03-23

No results posted yet for this study

Summary

Background: Diabetes mellitus (DM) is well known for long-term complications to general and oral health. Periodontal disease has a bidirectional association with the development of type 2 diabetes (T2DM) (Mealey, 2006; Taylor, 2001; Demmer et el.,2008). However, current literature conflicts with regards to dental caries incidence in patients with T2DM (Sampaio, Mello and Alves, 2011).

Objective: To investigate potential protective and risk factors for dental caries among T2DM with vitamin D and HbA1c using clinical, salivary and microbial analyses.

Methods: This project is a case-control clinical study. The study will be conducted at Royal London Dental Hospital, Institute of Dentistry, Bart's Health NHS Trust, London, UK. This study will aim to recruit 182 participants in total with diabetes (type 2), aged ≥18 male or female and participants will be cross-matched with non-diabetes according to age and gender.

Each participant will undergo a baseline screening for around 60 minutes where all the following assessments will be carried out; Caries risk assessment (CAMBRA), Plaque index, International Caries Detection and Assessment System (ICDAS) and Laser fluorescence evaluator (SOPRLIFE®, Acteon, France) and Oral behavioural and sociodemographic background will be collected.

Prior to the clinical study, there will be a laboratory based study using extracted teeth. The aim of this ex-vivo study is to assess the autofluorescence variation in dental carious lesions and compare this with International Caries Detection and Assessment System (ICDAS).

Conditions

  • Diabetes Mellitus, Type 2
  • Dental Caries

Sponsors & Collaborators

  • The Novo Nordisk UK Research Foundation

    collaborator UNKNOWN

  • Queen Mary University of London

    lead OTHER

Principal Investigators

  • AShwaq Alkahtani, BSc,MSc · Queen May University of London

Eligibility

Min Age
18 Years
Sex
ALL
Healthy Volunteers
Yes

Timeline & Regulatory

Start
2020-12-15
Primary Completion
2021-11-02
Completion
2021-11-02

Countries

  • United Kingdom

Study Locations

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Read the full study record

This page highlights key information. For complete eligibility criteria, study locations, investigator contacts, and the full protocol, visit the original record on ClinicalTrials.gov.

View NCT04883086 on ClinicalTrials.gov