Effect of the Use of Symbiotics in Patients With Colon Cancer

Summary

Due to the high incidence, cancer and the concomitant presence of malnutrition are currently a worldwide public health problem. The loss of weight and body tissues is a common condition in cancer patients with lesions of the airways and digestive tract and is related to anorexia and the presence and duration of gastrointestinal symptoms, such as diarrhea. The latter directly interferes with the progression of enteral diets, which are administered in order to provide adequate nutritional support for the recovery of patients and nutritional status. In this sense, the importance of measures to help reduce diarrhea episodes is reinforced, aiming at the adequate infusion of enteral diets and, consequently, nutritional needs. It is known that the use of antimicrobials is closely related to the increased incidence of nasocomial diarrhea, as it facilitates colonization by pathogenic bacteria, such as Clostridium difficile. In addition, nosocomial diarrhea is a very relevant occurrence due to the financial burden it causes for the hospital institution, which can also worsen the patient's clinical condition, since he is weakened due to the underlying disease. Despite these important aspects, studies carried out with the aim of reducing diarrhea episodes in patients with airway and digestive lesions are still not described in the literature. In this context, the use of symbiotics presents itself as a possibly beneficial alternative, considering the role of probiotics and prebiotics in the modulation of intestinal function. In this sense, this work aims to evaluate the impact of perioperative supplementation with symbiotic on clinical outcomes and intestinal function of patients with colon cancer and digestive airways undergoing colorectal resection. It is assumed that the use of symbiotics could have better results than the use of probiotics and isolated prebiotics.

Conditions

• Symbiotic
• Cancer Colorectal
• Cancer Head Neck
• Intestinal Dysbiosis
• Diarrhea
• Intestinal Microbiota
• Nutritional Status

Interventions

DIETARY_SUPPLEMENT

Simbyotic

6 grams of the symbiotic will be administered twice a day

DEVICE

Control Group

6 grams of the maltodextrin will be administered twice a day

Sponsors & Collaborators

• Simone de Vasconcelos Generoso

  collaborator UNKNOWN

• Luísa Martins Trindade

  collaborator UNKNOWN

• Rodrigo Gomes Silva

  collaborator UNKNOWN

• Maria Isabel Toulson Davisson Correia

  collaborator UNKNOWN

• Federal University of Minas Gerais

  lead OTHER

Study Design

Allocation

RANDOMIZED

Purpose

PREVENTION

Masking

QUADRUPLE

Model

PARALLEL

Eligibility

Min Age

18 Years

Sex

ALL

Healthy Volunteers

No

Timeline & Regulatory

Start

2019-12-01

Primary Completion

2022-12-01

Completion

2022-12-01

Countries

• Brazil

Study Locations