Immune Responses to COVID-19 Vaccination in Lymphoma Patients
NCT04858568 · Status: COMPLETED · Type: OBSERVATIONAL · Enrollment: 592
Last updated 2024-02-06
Summary
This prospective observational study aims to evaluate the robustness and persistence of immune responses to vaccination, define factors associated with impaired immune responses and assess the incidence of COVID-19 infections in vaccinated individuals. To do this, we will collect peripheral blood from patients with lymphoid cancers before and after their COVID-19 vaccination. The blood will be explored in the laboratory for antibodies to SARS-CoV-2 and T-cell responses to the spike protein. Detailed clinical information will also be collated on about their cancer and treatment.
Conditions
- Classical Hodgkin Lymphoma
- Diffuse Large B Cell Lymphoma
- Primary Mediastinal B Cell Lymphoma
- High-grade B-cell Lymphoma
- Burkitt Lymphoma
- Follicular Lymphoma
- Mantle Cell Lymphoma
- Marginal Zone Lymphoma
- Chronic Lymphocytic Leukemia
- Small Lymphocytic Lymphoma
- Lymphoplasmacytic Lymphoma
- Nodular Lymphocyte Predominant Hodgkin Lymphoma
- Peripheral T-cell Lymphoma
Sponsors & Collaborators
-
University Hospital Southampton NHS Foundation Trust
lead OTHER
Eligibility
- Min Age
- 18 Years
- Sex
- ALL
- Healthy Volunteers
- No
Timeline & Regulatory
- Start
- 2021-03-11
- Primary Completion
- 2022-10-31
- Completion
- 2024-01-31
Countries
- United Kingdom
Study Locations
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