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Preoperative Lugol's Solution in Graves' Disease and Toxic Nodular Goiter

NCT04856488 · Status: RECRUITING · Phase: PHASE3 · Type: INTERVENTIONAL · Enrollment: 182

Last updated 2026-02-10

No results posted yet for this study

Summary

The purpose of this study is to assess if preoperative treatment with Lugol's solution prior to thyroidectomy can reduce the surgical complications hypoparathyroidism and laryngeal nerve palsy

Conditions

  • Hyperthyroidism

Interventions

DRUG

Iodine-Potassium Iodide 5%-10% Oral and Topical Solution

Iodine Potassium Iodide 5% oral solution, administered 3 times per day for 10 days

Sponsors & Collaborators

  • Jan Calissendorff

    lead OTHER

Principal Investigators

  • Jan Calissendorff, MD, PhD · Department of Molecular Medicine and Surgery, Karolinska Institutet

Study Design

Allocation
RANDOMIZED
Purpose
TREATMENT
Masking
NONE
Model
PARALLEL

Eligibility

Min Age
18 Years
Max Age
75 Years
Sex
ALL
Healthy Volunteers
No

Timeline & Regulatory

Start
2021-11-18
Primary Completion
2028-08-31
Completion
2028-12-31

Countries

  • Sweden

Study Locations

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Read the full study record

This page highlights key information. For complete eligibility criteria, study locations, investigator contacts, and the full protocol, visit the original record on ClinicalTrials.gov.

View NCT04856488 on ClinicalTrials.gov