MedTrace Logo

Cognition and Motor Learning Post-stroke

NCT04829071 · Status: RECRUITING · Phase: EARLY_PHASE1 · Type: INTERVENTIONAL · Enrollment: 65

Last updated 2025-11-04

No results posted yet for this study

Summary

This project seeks to determine how post-stroke cognitive impairment moderates motor learning during walking in older adults with chronic stroke and identify brain structural markers that mediate this relationship. The chosen experimental design integrates biomechanical analyses, neuropsychological assessments, and brain imaging techniques to determine the impact of post-stroke cognitive impairment severity on two forms of motor learning (explicit and implicit) and examine the role of the dorsolateral prefrontal cortex in the relationship between cognition and explicit motor learning. Ultimately, this work may lead to the development of a more comprehensive, effective treatment approach to improve walking dysfunction in older adults post-stroke.

Conditions

  • Stroke
  • CVA (Cerebrovascular Accident)

Interventions

BEHAVIORAL

Explicit motor learning

Participants will be provided with visual feedback of their right and left step lengths on a screen in front of a treadmill.

BEHAVIORAL

Implicit motor learning

Participants will walk on a treadmill that drives their right and left legs to move at two different speeds.

Sponsors & Collaborators

  • University of Southern California

    lead OTHER

Principal Investigators

  • Kristan Leech, PT, DPT, PhD · University of Southern California

Study Design

Allocation
NA
Purpose
BASIC_SCIENCE
Masking
NONE
Model
SINGLE_GROUP

Eligibility

Min Age
45 Years
Max Age
85 Years
Sex
ALL
Healthy Volunteers
No

Timeline & Regulatory

Start
2023-01-16
Primary Completion
2026-08-14
Completion
2026-12-14

Countries

  • United States

Study Locations

More Related Trials

Entities

Diseases

Read the full study record

This page highlights key information. For complete eligibility criteria, study locations, investigator contacts, and the full protocol, visit the original record on ClinicalTrials.gov.

View NCT04829071 on ClinicalTrials.gov