Prediction of Outcomes After Surgery for Unruptured Intracranial Aneurysms

Summary

Accurate preoperative identification of patients at high risk for adverse outcomes would be clinically advantageous, as it would allow enhanced resource preparation, better surgical decision-making, enhanced patient education and informed consent, and potentially even modification of certain modifiable risk factors. The aim of the Prediction of adverse events after microsurgery for intracranial unruptured aneurysms (PRAEMIUM) study is therefore to develop and externally validate a clinically applicable, robust ML-based prediction tool based on multicenter data from a range of international centers.

Conditions

• Aneurysm, Brain

Interventions

PROCEDURE

Microsurgery

Microsurgery for unruptured intracranial aneurysm

Sponsors & Collaborators

• Macquarie University, Australia

  collaborator OTHER

• University of Melbourne

  collaborator OTHER

• Kepler University Hospital

  collaborator OTHER

• Medical University Innsbruck

  collaborator OTHER

• General University Hospital, Prague

  collaborator OTHER

• Universitätsklinikum Köln

  collaborator OTHER

• Goethe University

  collaborator OTHER

• University Medical Center Mainz

  collaborator OTHER

• University of Göttingen

  collaborator OTHER

• University Hospital Dresden

  collaborator OTHER

• Charite University, Berlin, Germany

  collaborator OTHER

• Heinrich-Heine University, Duesseldorf

  collaborator OTHER

• University of Roma La Sapienza

  collaborator OTHER

• University of Padova

  collaborator OTHER

• University of Florence

  collaborator OTHER

• Fondazione I.R.C.C.S. Istituto Neurologico Carlo Besta

  collaborator OTHER

• University of Messina

  collaborator OTHER

• Universita di Verona

  collaborator OTHER

• Uniuversity of Genua, Italy

  collaborator OTHER

• Leiden University Medical Center

  collaborator OTHER

• Academisch Medisch Centrum - Universiteit van Amsterdam (AMC-UvA)

  collaborator OTHER

• UMC Utrecht

  collaborator OTHER

• Burdenko Neurosurgery Institute

  collaborator OTHER

• Sahlgrenska University Hospital

  collaborator OTHER

• University of Bern

  collaborator OTHER

• Barrow Neurological Institute

  collaborator OTHER

• Stanford University

  collaborator OTHER

• Emory University

  collaborator OTHER

• University of Wisconsin, Madison

  collaborator OTHER

• University of California, San Francisco

  collaborator OTHER

• University of Illinois at Chicago

  collaborator OTHER

• Brigham and Women's Hospital

  collaborator OTHER

• Mayo Clinic

  collaborator OTHER

• University of California, Los Angeles

  collaborator OTHER

• Endeavor Health

  collaborator OTHER

• Fondazione Policlinico Universitario Agostino Gemelli IRCCS

  collaborator OTHER

• University of Zurich

  lead OTHER

Principal Investigators

• Victor Staartjes · USZ

• Giuseppe Esposito · USZ

Eligibility

Min Age

18 Years

Sex

ALL

Healthy Volunteers

No

Timeline & Regulatory

Start

2021-05-20

Primary Completion

2022-01-01

Completion

2022-10-01

Countries

• United States
• Australia
• Austria
• Czechia
• Germany
• Italy
• Netherlands
• Russia
• Sweden
• Switzerland

Study Locations