Collaborative Network for Generating Scientific Evidence in COVID-19 For the Unified Health System in Brazil - RECOVER SUS-BRASIL

Summary

The RECOVER SUS-BRASIL network, made up of excellent academic and research institutions, was formed in response to the emergence of unprecedented public health related to SARS-CoV-2. The Network's objectives are the production of scientific knowledge, the technical and scientific strengthening of participating centers, the sharing of information and experiences with other assistance services and the generation of evidence for public health policies in Brazil. The present proposal aims to increase the magnitude of the Network, proposing two studies to assess the epidemic of COVID-19 in Brazil. The first study deals with the establishment of a prospective cohort of patients hospitalized for COVID-19. Through using standardized data collection procedures, biological samples and biomarkers, this study will be able to describe clinical presentation, severity, risk factors for worsening of the disease. Multiple clinical outcomes of severity of disease, organ dysfunction, hospital mortality, length of hospital stay, hospital readmission and early post-discharge death. Will be biomarkers of inflammation, cellular and humoral immunity were also evaluated to study their association with clinical outcomes, variability of SARS-CoV-2 and the development of immunity in infected individuals through the detection and titration of neutralizing antibodies anti-SARS-CoV-2. The second study 2 will evaluate the COVID-19 epidemic in people living with HIV / AIDS, using SUS databases, such as SIM, SICLOM and SISCEL. This study is particularly relevant since on the one hand it includes a population potentially at greater risk of developing severe forms of the disease, given their underlying condition, as, on the other hand, they are exposed chronically to drugs that could potentially have an effect on SARS-CoV-2. Finally, a major objective of RECOVER SUS-BRASIL is integrate technical and scientific capacities generating scientific production of high relevance and impact and strengthening health and science throughout the country.

Conditions

• Covid19
• Hospitalization

Interventions

OTHER

Data collection

Clinical and sociodemographic data collected through interview at admission and results of complementary tests performed during hospitalization.

Sponsors & Collaborators

• Hospital Universitario Pedro Ernesto

  collaborator OTHER

• Universidade Federal do Rio de Janeiro

  collaborator OTHER

• Hospital Couto Maia/SES/BA

  collaborator UNKNOWN

• Hospital São José de Doenças Infecciosas - HSJ / Secretaria de Saúde Fortaleza

  collaborator UNKNOWN

• Hospital Estadual Sumaré Dr. Leandro Francheschini

  collaborator UNKNOWN

• Universidade Federal de Santa Maria

  collaborator OTHER

• Hospital Regional de São José - Dr. Homero de Miranda Gomes

  collaborator OTHER

• Hospital dos Servidores do Estado do Rio de Janeiro

  collaborator OTHER_GOV

• Federal University of Minas Gerais

  collaborator OTHER

• Gaffree & Guinle Universitary Hospital

  collaborator OTHER

• Hospital Nossa Senhora da Conceicao

  collaborator OTHER

• Instituto de Infectologia Emílio Ribas

  collaborator UNKNOWN

• Evandro Chagas National Institute of Infectious Disease

  lead OTHER

Eligibility

Min Age

18 Years

Sex

ALL

Healthy Volunteers

No

Timeline & Regulatory

Start

2020-07-25

Primary Completion

2021-10-25

Completion

2022-03-25

Countries

• Brazil

Study Locations