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Clinical and Mechanistic Study of Patients (With COVID-19 or Not) With a Recent Acrosyndrome

NCT04590209 · Status: WITHDRAWN · Phase: NA · Type: INTERVENTIONAL

Last updated 2026-03-12

No results posted yet for this study

Summary

The recent and unexpected occurrence of patients with the development of skin lesions on the hands and/ or feet has been described recently. As these cases occurred contemporaneously with the Coronavirus Disease 2019 (COVID-19) and as it was the most often occurrence of de novo frostbites, the question raised of whether there is a direct link between the occurrence of these lesions and infection of the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) the responsible for CoVID-19. Indeed, mechanisms of these lesions and the precise correlation with Sars-CoV-2 remains poorly understood. Therefore, this study aim to:

1. Determine the possible link with this virus,
2. Understand the mechanisms involved in the pathogenesis of these lesions.

Conditions

  • Adult Patients With Lesions on Fingers or Toes

Interventions

OTHER

Blood sampling

Recruited patients will be subjected to 2 blood samples of 7 mL at day 0 for serological analysis and cell collection and to an additional blood sample of 7 mL at day 15 for serological analysis

OTHER

Skin biopsy

Recruited patients will be subjected to a single skin biopsy at day 0 for histological and transcriptomic analysis

Sponsors & Collaborators

  • Institut Cochin

    collaborator OTHER

  • URC-CIC Paris Descartes Necker Cochin

    collaborator OTHER

  • Assistance Publique - Hôpitaux de Paris

    lead OTHER

Principal Investigators

  • Sélim Aractingi, MD, PhD · Tarnier Hospital, AP-HP

  • Nicolas Dupin, MD, PhD · Tarnier Hospital, AP-HP

Study Design

Allocation
NA
Purpose
BASIC_SCIENCE
Masking
NONE
Model
SINGLE_GROUP

Eligibility

Min Age
18 Years
Sex
ALL
Healthy Volunteers
No

Timeline & Regulatory

Start
2023-01-31
Primary Completion
2023-03-31
Completion
2023-03-31

Countries

  • France

Study Locations

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Read the full study record

This page highlights key information. For complete eligibility criteria, study locations, investigator contacts, and the full protocol, visit the original record on ClinicalTrials.gov.

View NCT04590209 on ClinicalTrials.gov