In Utero Magnesium Sulfate Exposure: Effects on Extremely-Low-Birth-Weight Infants

Summary

This study examined the effect of magnesium sulfate (MgSO4) exposure on adverse outcome in extremely low birth weight (ELBW) infants. For infants included in the NICHD Neonatal Research Network Generic Database whose mothers were given prenatal MgSO4, data were prospectively collected on maternal/infant conditions and magnesium exposure (including indications, timing and duration of exposure).

Conditions

• Infant, Newborn
• Infant, Low Birth Weight
• Infant, Small for Gestational Age
• Infant, Premature
• Intracranial Hemorrhages
• Leukomalacia, Periventricular
• Cerebral Palsy

Sponsors & Collaborators

• National Center for Research Resources (NCRR)

  collaborator NIH

• NICHD Neonatal Research Network

  lead NETWORK

Principal Investigators

• James A. Lemons, MD · Indiana University

• Waldemar A. Carlo, MD · University of Alabama at Birmingham

• William Oh, MD · Brown University, Womens and Infants Hospital

• Avroy A. Fanaroff, MD · Case Western Reserve University, Rainbow Babies & Children's Hospital

• Edward F. Donovan, MD · Children's Hospital Medical Center, Cincinnati

• Barbara J. Stoll, MD · Emory University

• Ann R. Stark, MD · Brigham and Women's Hospital

• Charles R. Bauer, MD · University of Miami

• Lu-Ann Papile, MD · University of New Mexico

• David K. Stevenson, MD · Stanford University

• Sheldon B. Korones, MD · University of Tennessee

• Jon E. Tyson, MD MPH · University of Texas Southwestern Medical Center

• Seetha Shankaran, MD · Wayne State University

• Richard A. Ehrenkranz, MD · Yale University

• Raymond Bain, PhD · George Washington University

Eligibility

Max Age

14 Days

Sex

ALL

Healthy Volunteers

Yes

Timeline & Regulatory

Start

1996-07-31

Primary Completion

1998-06-30

Completion

2000-06-30

Countries

• United States

Study Locations