Unhide® Project: A Digital Health Platform to Collect Lifestyle Data for Brain Inflammation Research

Summary

The unhide® Project is a non-interventional, longitudinal research study designed to establish a secure data repository of demographic, health, and lifestyle information from individuals with brain inflammation and related neuroinflammatory conditions. Participants in the United States aged 2 years and older will provide self-reported health data, biometrics, and symptom diaries through the MyDataHelps™ app (branded as unhide® for this study). The goal is to create comprehensive longitudinal profiles to facilitate research into disease subtypes, causes, diagnostics, and potential treatments, as well as to identify potential participants for future optional studies. "Healthy" individuals without brain inflammation are also eligible to participate.

The digital health research platform used in this study was originally developed and designed by Solve M.E and was called SolveTogether. The Brain Inflammation Collaborative (BIC) expanded upon Solve M.E.'s work to include related diagnoses, pediatric participants, enhance symptom tracking, and more. BIC and Solve M.E. combined Solve Together and unhide®, to create The unhide® Solve Together Unified Platform in 2025.

Conditions

• Post-Acute COVID-19 Syndrome
• ME/CFS
• Rheumatic Arthritis
• Juvenile Rheumatoid Arthritis (JRA)
• Psoriatic Arthritis (PsA)
• Ankylosing Spondylitis (AS)
• Autoimmune Encephalitis
• Celiac Disease
• Celiac Disease in Children
• Chronic Lyme Disease
• Post-treatment Lyme Disease Syndrome
• Crohn's Disease
• Dysautonomia
• Anorexia Nervosa
• Bulimia Nervosa
• ARFID
• Avoidant / Restrictive Food Intake Disorder
• Ehlers Danlos Syndrome
• Endometriosis
• Fibromyalgia (FM)
• Long COVID
• Lupus
• Migraines
• Mast Cell Activation Syndrome
• Multiple Sclerosis
• Myalgic Encephalomyelitis (ME)
• Myasthenia Gravis, Generalized
• Myasthenia Gravis in Children
• Narcolepsy
• Obsessive Compulsive Disorder (OCD)
• PANDAS
• Pediatric Acute-onset Neuropsychiatric Syndrome (PANS)
• POTS - Postural Orthostatic Tachycardia Syndrome
• General Anxiety Disorder, Social Anxiety Disorder
• PTSD - Post Traumatic Stress Disorder
• Psoriasis
• Traumatic Brain Injury
• Tourette's Syndrome
• Inflammatory Bowel Disease (IBD)
• Autoimmune Diseases
• Neurological Diseases or Conditions
• Psychiatric Disorder
• Sjogren's Syndrome
• Ulcerative Colitis and Crohn's Disease

Sponsors & Collaborators

• Solve ME/CFS Initiative

  collaborator OTHER

• Care Evolution

  collaborator UNKNOWN

• Columbia University

  collaborator OTHER

• Brain Inflammation Collaborative

  lead OTHER

Principal Investigators

• Megan L Fitzgerald, PhD · Brain Inflammation Collaborative

Eligibility

Min Age

2 Years

Sex

ALL

Healthy Volunteers

Yes

Timeline & Regulatory

Start

2023-07-05

Primary Completion

2030-06-30

Completion

2030-12-31

Countries

• United States

Study Locations