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Genetic Studies of Strabismus, Congenital Cranial Dysinnervation Disorders (CCDDs), and Their Associated Anomalies

NCT03059420 · Status: RECRUITING · Type: OBSERVATIONAL · Enrollment: 20000

Last updated 2026-02-11

No results posted yet for this study

Summary

The purpose of this study is to identify genes associated with impaired development and function of the cranial nerves and brainstem, which may result in misalignment of the eyes (strabismus) and related conditions.

Conditions

  • Congenital Fibrosis of Extraocular Muscles
  • Duane Retraction Syndrome
  • Duane Radial Ray Syndrome
  • Mobius Syndrome
  • Brown Syndrome
  • Marcus Gunn Syndrome
  • Strabismus Congenital
  • Horizontal Gaze Palsy
  • Horizontal Gaze Palsy With Progressive Scoliosis
  • Facial Palsy
  • Facial Paresis, Hereditary, Congenital
  • Third Nerve Palsy
  • Fourth Nerve Palsy
  • Sixth Nerve Palsy
  • Synkinesis
  • Ocular Motility Disorders
  • Levator-Medial Rectus Synkinesis
  • Athabaskan Brainstem Dysgenesis
  • Tongue Paralysis
  • Ninth Nerve Disorder
  • Fifth Nerve Palsy
  • Seventh Nerve Palsy
  • Eleventh Nerve Disorder
  • Twelfth Nerve Disorder
  • Vagus Nerve Paralysis
  • Moebius Sequence

Sponsors & Collaborators

Principal Investigators

  • Elizabeth Engle, MD · Boston Children's Hospital

Eligibility

Min Age
1 Day
Sex
ALL
Healthy Volunteers
Yes

Timeline & Regulatory

Start
2004-02-01
Primary Completion
2030-01-31
Completion
2030-01-31

Countries

  • United States

Study Locations

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Entities

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Read the full study record

This page highlights key information. For complete eligibility criteria, study locations, investigator contacts, and the full protocol, visit the original record on ClinicalTrials.gov.

View NCT03059420 on ClinicalTrials.gov