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The Impact of Covid-19 on Skeletal Muscle

NCT04756674 · Status: WITHDRAWN · Type: OBSERVATIONAL

Last updated 2023-06-02

No results posted yet for this study

Summary

With the recent worldwide outbreak of the COVID-19 infection and the huge impact it has had upon lives in the UK, it is key to increase knowledge on the impact of the virus on the body. Certain aspects of the virus' characteristics are also poorly understood: The reason behind the variation in response between individuals, and the long-term impacts of infection upon the body. It is already known from previous research that muscle-health plays an important role in health, with other illnesses known to have an impact upon muscle health. A large number of studies have investigated the relationship between muscle and health, with an increasing focus upon the impact upon the mitochondria within the muscle cells. Mitochondria are the energy-producing component of a cell and are vital not just for the muscle-cells but for the body as a whole.

The researchers hope that by investigating the impact of COVID-19 infection upon human skeletal muscle, the question of why individuals have different responses to the infection and the mechanism of the longer-term impact of infection can be answered. This added knowledge will then, hopefully, be able to guide therapy targets in the future.

Conditions

  • Covid19
  • Muscle Loss
  • Mitochondrial Alteration

Interventions

OTHER

No intervetion will be used

No intervention will be used

Sponsors & Collaborators

  • University of Nottingham

    lead OTHER

Principal Investigators

  • Beth Phillips, BSc PhD · University of Nottingham

Eligibility

Min Age
40 Years
Sex
ALL
Healthy Volunteers
No

Timeline & Regulatory

Start
2021-03-10
Primary Completion
2022-10-01
Completion
2022-10-01

Countries

  • United Kingdom

Study Locations

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Read the full study record

This page highlights key information. For complete eligibility criteria, study locations, investigator contacts, and the full protocol, visit the original record on ClinicalTrials.gov.

View NCT04756674 on ClinicalTrials.gov