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Preference of Protein Intake and FTO rs1558902 Gene Polymorphism Among Women Obese

NCT04740528 · Status: COMPLETED · Type: OBSERVATIONAL · Enrollment: 130

Last updated 2021-03-02

No results posted yet for this study

Summary

The concept personalized gene-based nutrition combines genetic information with specific dietary intake that is crucial in managing obesity. Obesity experienced by adult women is generally caused by inapproriate diet and sedentary lifestyle. Variations in the fat mass and obesity-related gene (FTO) has been linked with susceptibility to obesity, but diet seems to change the relationship. A single nucleotide polymorphism (SNP) in the fat mass and obesity-associated gene (FTO) is a potent predictor of human obesity. Higher protein diets were more appropriate than standard protein diets, and frequently recommended as a weight loss plan as it prevents the loss of lean tissue mass. Nevertheless, high intakes of proteins may adversely affect metabolic functions. Multi studies have explored associated FTO polymorphisms with obesity in different populations. However, the contribution of the FTO common variants to obesity is controversial in Asian people, some studies showed rs1558902 was statistically associated with BMI, but other results reported FTO gene is not statistically associated with obesity. Given the diversity of Asian populations, the investigators generated a hypothesis whether relations between preference protein intake and FTO rs1558902 gene polymorphism exist in selected Indonesian obesity women

Conditions

  • Obesity Adult Onset

Interventions

DIAGNOSTIC_TEST

fto gene testing

Blood samples were collected after a 12-h fasting by Prodia Laboratory for DNA isolation and biochemical analysis

Sponsors & Collaborators

  • Universitas Diponegoro

    lead OTHER

Principal Investigators

  • Etika Noer, PhD · Diponegoro University

Eligibility

Min Age
35 Years
Max Age
45 Years
Sex
FEMALE
Healthy Volunteers
Yes

Timeline & Regulatory

Start
2020-08-01
Primary Completion
2020-10-01
Completion
2020-11-30

Countries

  • Indonesia

Study Locations

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Read the full study record

This page highlights key information. For complete eligibility criteria, study locations, investigator contacts, and the full protocol, visit the original record on ClinicalTrials.gov.

View NCT04740528 on ClinicalTrials.gov