Impact of Fentanyl Analgesia on the Accuracy of HVPG Measurements in Patients With Portal Hypertension

Summary

Portal hypertension is a common complication of chronic liver disease and is associated with most clinical consequences of cirrhosis. The most reliable method for assessing portal hypertension is the measurement of the hepatic venous pressure gradient (HVPG). The HVPG is the gold-standard methods for assessing clinically significant portal hypertension and becoming increasingly used clinically. It is useful in the differential diagnosis of portal hypertension and provides a prognostic index in cirrhotic patients. Many patients are painful and reluctant to undergo serial HVPG measurements. But interventionists are reluctant to use analgesics because they always pay more attention to the accuracy of HVPG measurements.Although Adam F. et al concluded that low-dose midazolam sedation is an option for patients undergoing serial hepatic venous pressure measurements (Hepatology 1999), the effects of using opioid analgesics alone on hepatic venous pressure measurements have not yet been defined. The objective of this study was to evaluate the effects of fentanyl on the HVPG.

Conditions

• Liver Cirrhosis
• Portal Hypertension
• Pain

Interventions

DRUG

Fentanyl

To assess the accuracy of HVPG in TIPS after injecting a dose of 1\~2 mg/kg fentanyl.

Sponsors & Collaborators

• LanZhou University

  collaborator OTHER

• Lishui hospital of Zhejiang University

  collaborator UNKNOWN

• The First Affiliated Hospital with Nanjing Medical University

  collaborator OTHER

• Zhejiang University

  collaborator OTHER

• Hepatopancreatobiliary Surgery Institute of Gansu Province

  lead OTHER

Principal Investigators

• Xiaolong Qi, MD · LanZhou University

• Xun Li, MD · LanZhou University

• Haijun Zhang, MD · LanZhou University

• Lei Li, MD · LanZhou University

• Zhongwei Zhao, MD · Lishui hospital of Zhejiang University

• Jiansong Ji, PHD · Lishui hospital of Zhejiang University

• Chuan guang Wang, Master · Lishui hospital of Zhejiang University

• Wei Wu · Lishui hospital of Zhejiang University

• Lili Yang · Lishui hospital of Zhejiang University

• Yulan Li, MD · LanZhou University

• YuJiang Yin · LanZhou University

• Wei Yang, master · The First Affiliated Hospital with Nanjing Medical University

• Zi Niu Yu, MD · Zhejiang University

• Wentao Wu, master · The First Affiliated Hospital with Nanjing Medical University

• Xujun Yang, master · LanZhou University

• Shuangxi Li · LanZhou University

• Fangyu Xu · LanZhou University

• Weizhong Zhou, MD · The First Affiliated Hospital with Nanjing Medical University

Study Design

Allocation

NA

Purpose

TREATMENT

Masking

NONE

Model

SINGLE_GROUP

Eligibility

Min Age

18 Years

Max Age

75 Years

Sex

ALL

Healthy Volunteers

No

Timeline & Regulatory

Start

2022-01-01

Primary Completion

2024-11-01

Completion

2024-11-01

Countries

• China

Study Locations