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Danish Study of Non-Invasive Diagnostic Testing in Coronary Artery Disease 3

NCT04707859 · Status: UNKNOWN · Type: OBSERVATIONAL · Enrollment: 1000

Last updated 2021-01-29

No results posted yet for this study

Summary

In a cohort of symptomatic patients referred to coronary computed tomography angiography (CCTA), the investigators aim is:

1. To investigate and compare the diagnostic precision of Rubidium Positron Emission Tomography (Rb PET) and 15O-water PET (15O-water PET) in patients where CCTA does not exclude obstructive coronary artery disease (CAD) using invasive coronary angiography with fractional flow reserve (ICA-FFR) as reference standard.
2. To study the diagnostic accuracy and prognostic value of computed tomography fractional flow reserve (CT-FFR) in patients where CCTA does not exclude obstructive CAD with ICA-FFR as reference standard.
3. To validated a pre-test probability model including genetic and circulating biomarkers.
4. To identify and characterize genetic risk variants and circulating biomarkers importance in developing CAD.
5. To evaluate the bone mineral density in the hip and spine and correlate this to the degree of vascular calcification.

Conditions

Interventions

DIAGNOSTIC_TEST

Head to head comparison: Rubidium vs 15O-water PET

Head to head comparison with invasive FFR as reference. Adjustment for abnormal microcirculation

Sponsors & Collaborators

  • University of Aarhus

    lead OTHER

Principal Investigators

  • Simon Winther, MD, PhD · Hospital Unit West, Herning, Denmark

Eligibility

Min Age
30 Years
Max Age
100 Years
Sex
ALL
Healthy Volunteers
No

Timeline & Regulatory

Start
2021-01-05
Primary Completion
2022-07-05
Completion
2023-01-05

Countries

  • Denmark

Study Locations

More Related Trials

Entities

Diseases

Read the full study record

This page highlights key information. For complete eligibility criteria, study locations, investigator contacts, and the full protocol, visit the original record on ClinicalTrials.gov.

View NCT04707859 on ClinicalTrials.gov