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Pharmacokinetics of Morphine and Oxycodone in Frail Elderly Undergoing Cardiac Surgery

NCT04696445 · Status: COMPLETED · Type: OBSERVATIONAL · Enrollment: 34

Last updated 2022-06-23

No results posted yet for this study

Summary

* Single centre observational cohort study.
* 20 older patients undergoing cardiac surgery who receive standard of care pain treatment.
* Postoperative ICU: blood sampling to determine morphine and metabolite (M3G, M6G, noroxycodone and oxymorphone) pharmacokinetics
* After ICU discharge on general ward: blood sampling to determine morphine, oxycodone and metabolite (M3G, M6G, noroxycodone and oxymorphone) pharmacokinetics
* During study monitoring of pain scores, total opioid consumption, side effects (e.g. nausea, vomiting, pruritus), sedation and delirium scores.

Conditions

  • Opioid Use
  • Side Effect of Drug
  • Postoperative Pain

Interventions

DRUG

Morphine & Oxycodone

Morphine and Oxycodone are used in daily practice as part of standard care. Morphine and Oxycodone will be acquired through the clinical pharmacy of St Antonius and administered according to the standard postoperative pain protocol.

Sponsors & Collaborators

  • Academisch Medisch Centrum - Universiteit van Amsterdam (AMC-UvA)

    collaborator OTHER

  • St. Antonius Hospital

    lead OTHER

Eligibility

Min Age
70 Years
Sex
ALL
Healthy Volunteers
No

Timeline & Regulatory

Start
2020-10-01
Primary Completion
2021-11-26
Completion
2021-11-26

Countries

  • Netherlands

Study Locations

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Read the full study record

This page highlights key information. For complete eligibility criteria, study locations, investigator contacts, and the full protocol, visit the original record on ClinicalTrials.gov.

View NCT04696445 on ClinicalTrials.gov